The rise of atopy and links to infection
The rise of atopy and links to infection
复制标题
特应性的增加及其与感染的联系
DOI：
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复制
发表时间：
2002
期刊：
影响因子：
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通讯作者：
J. Hopkin
中科院分区：
文献类型：
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作者：
J. Hopkin
特应性是对常见环境抗原过敏的状态。遗传和环境因素促进了这种疾病。流行率的显著上升主要集中在世界各地的社会经济发达社区，强调了环境因素在塑造这种免疫疾病方面的强大作用，其特征是Th-2免疫机制和IgE产生受到不充分的限制。扭转流行病趋势取决于我们确定主要的环境投入并采取行动消除这些投入。到目前为止，这些环境因素的性质仍有待澄清。候选因素包括发达国家的饮食变化、化学空气污染和微生物暴露。本文将其范围限制在改变微生物暴露作为一种潜在机制。(a)它记录了与特应性状态相关的流行病学数据，这些特应性状态与自然暴露于病原体，寄生虫和肠道微生物较少有关，但与早期生活中暴露于某些抗生素和公共卫生免疫接种有关。(b)它记录了对小鼠的研究，这些研究支持某些微生物暴露可以抑制实验性过敏的概念。(c)它考虑了这种作用的潜在免疫机制，包括某些自然感染促进免疫调节过程的可能性，这些免疫调节过程可以抑制特应性。它的结论是，假设微生物暴露的变化模式可能促进了过敏性反应的上升是可行的，并扭转过敏性反应的上升，令人兴奋的可能性可能来自进一步的研究。
Atopy is the state of allergy to common environmental antigens. Genetic and environmental factors promote the disorder. The impressive rise in prevalence, mainly centred on socio‐economically developed communites around the world, emphasizes the potent action of environmental factors in moulding this immune disorder which is characterized by inadequately restrained Th‐2 immune mechanisms and IgE production. Reversing the epidemiological trend depends on our identifying the major environmental inputs and acting against these. As yet, the nature of these environmental factors remains to be clarified. Candidate factors include changes in diet, chemical air pollution and microbial exposures in developed countries. This article limits its scope to changing microbial exposures as a potential mechanism. (a) It records epidemiological data that have associated atopic status with less natural exposure to pathogens, parasites and commensal micro‐organisms, but with more exposure to certain antibiotics and public health immunizations in early life. (b) It records studies in mice that support the concept that certain microbial exposures can inhibit experimental allergy. (c) It considers potential immune mechanisms for such an action, including the possibility that certain natural infections promote immune regulatory processes that can restrain atopy. It is concluded that the hypothesis that changing patterns of microbial exposure may have promoted the rise in atopy is viable, and that exciting possibilities for reversing the rise of atopy may be derived from further studies.
影响因子：
158.5
作者：
Ball, TM;Castro-Rodriguez, JA;Wright, AL
通讯作者：
Wright, AL