Neural regulation of endocrine and autonomic stress responses.
Neural regulation of endocrine and autonomic stress responses.
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DOI：
10.1038/nrn2647
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发表时间：
2009-06
影响因子：
34.7
通讯作者：
Herman, James P
中科院分区：
文献类型：
--
作者：
Ulrich-Lai, Yvonne M;Herman, James P
所有物种的生存和福祉都需要对环境和稳态挑战做出适当的生理反应。体内平衡的重建和维持需要神经内分泌和自主应激系统的协调激活和控制。这些集体应激反应是通过边缘前脑、下丘脑和脑干中大量重叠的回路介导的，因此神经内分泌系统和自主神经系统的各自贡献根据应激源的形式或强度进行调整。负责调节压力反应的边缘区域与负责记忆和奖励的回路交叉，提供了一种根据先前经验和预期结果调整压力反应的方法。
The survival and well-being of all species requires appropriate physiological responses to environmental and homeostatic challenges. The reestablishment and maintenance of homeostasis entails the coordinate activation and control of neuroendocrine and autonomic stress systems. These collective stress responses are mediated via largely overlapping circuits in the limbic forebrain, hypothalamus and brainstem, so that the respective contribution of the neuroendocrine and autonomic systems is tuned in accordance with stressor modality or intensity. Limbic regions that are responsible for regulating stress responses intersect with circuits that are responsible for memory and reward, providing a means to tailor the stress response with respect to prior experience and anticipated outcomes.