Inflammatory cell signaling following exposures to particulate matter and ozone
Inflammatory cell signaling following exposures to particulate matter and ozone
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暴露于颗粒物和臭氧后的炎症细胞信号传导。
DOI：
10.1016/j.bbagen.2016.03.030
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发表时间：
2016-12-01
影响因子：
3
通讯作者：
Wu, Weidong
中科院分区：
文献类型：
--
作者：
Yan, Zhen;Jin, Yuefei;Wu, Weidong
背景：颗粒物（PM）和臭氧（O-3）是两种主要的环境空气污染物。流行病学和毒理学研究表明，暴露于这些污染物与各种不良健康影响，包括心血管和呼吸系统疾病，其中炎症被认为是一个共同的和必不可少的factor.Scope的审查：本次审查主要集中在主要的炎症细胞信号通路引发的暴露于PM和O-3。本文综述了EGF受体、Toll样受体和NOD样受体。在这篇评论中描述的细胞内信号蛋白激酶是磷脂酰肌醇3-激酶和丝裂原活化蛋白激酶。主要结论：暴露于PM或O-3可以激活细胞信号网络，包括膜受体、细胞内激酶和磷酸酶，以及调节炎症反应的转录因子。虽然PM诱导的细胞信号传导与所得ROS相关，但O-3诱导的细胞信号传导涉及磷酸盐。值得注意的是，PM和O-3暴露诱导的细胞信号传导随这些污染物的细胞类型和理化性质而变化。一般意义：细胞信号传导在炎症发病机制的调节中起着关键作用。阐明由PM或O-3启动的细胞信号通路不仅有助于揭示空气污染物的毒性机制，而且可以为开发针对空气污染引起的疾病的干预措施提供线索。(C)© 2016 Elsevier B. V.版权所有。
Background: Particulate matter (PM) and ozone (O-3) are two major ambient air pollutants. Epidemiological and toxicological studies have demonstrated exposure to these pollutants is associated with a variety of adverse health effects, including cardiovascular and respiratory disease, in which inflammation is believed to be a common and essential factor.Scope of review: This review mainly focuses on major inflammatory cell signaling pathways triggered by exposure to PM and O-3. The receptors covered in this review include the EGF receptor, toll like receptor, and NOD-like receptor. Intracellular signaling protein kinases depicted in this review are phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Activation of antioxidant and inflammatory transcription factors such as NrF2 and NF kappa B induced by PM and O-3 is also discussed.Major conclusions: Exposure to PM or O-3 can activate cellular signaling networks including membrane receptors, intracellular kinases and phosphatases, and transcription factors that regulate inflammatory responses. While PM induced cell signaling is associated with resultant ROS, O-3-induced cell signaling implicates phosphates. Notably, the cellular signaling induced by PM and O-3 exposure varies with cell type and physiochemical properties of these pollutants.General significance: Cellular signaling plays a critical role in the regulation of inflammatory pathogenesis. Elucidation of cellular signaling pathways initiated by PM or O-3 cannot only help to uncover the mechanisms of air pollutant toxicity but also provide clues for development of interventional measures against air pollution-induced disorders. (C) 2016 Elsevier B.V. All rights reserved.