Visual Contrast Sensitivity Improvement by Right Frontal High-Beta Activity Is Mediated by Contrast Gain Mechanisms and Influenced by Fronto-Parietal White Matter Microstructure.
Visual Contrast Sensitivity Improvement by Right Frontal High-Beta Activity Is Mediated by Contrast Gain Mechanisms and Influenced by Fronto-Parietal White Matter Microstructure.
复制标题
右额叶高 Beta 活动改善视觉对比敏感度是由对比增益机制介导的，并受额顶白质微观结构的影响。
DOI：
10.1093/cercor/bhv060
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Valero-Cabré,Antoni
中科院分区：
文献类型：
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作者：
Quentin,Romain;ElkinFrankston,Seth;Vernet,Marine;Toba,MonicaN;Bartolomeo,Paolo;Chanes,Lorena;Valero-Cabré,Antoni
对人类和非人类灵长类动物的行为和电生理研究表明，额叶高β活动与内源性注意力定向有关，并表明后者的功能能够调节视觉表现。我们结合节律性经颅磁刺激（TMS）和扩散成像来研究额叶振荡活动与视觉表现之间的关系，并将这些现象与人类的一组特定白质通路联系起来。采用经颅磁刺激诱导右侧额叶视野（FEF）的高β节律性活动，并记录其对对比敏感度函数的因果关系，以探讨其在不同刺激对比度水平下提高视觉检测性能的能力。我们的研究结果表明，参与右FEF的特定频率活动模式有能力诱导心理测量功能向左移动。在不同水平的刺激对比下，视觉表现的增加可能是由对比增益机制介导的。有趣的是，白质连通性的微观结构测量表明，连接FEF和顶叶内沟的右侧额-顶叶连通性在大脑网络中传播高-节律信号，并对自上而下的额叶影响视觉表现有强烈的暗示。
Behavioral and electrophysiological studies in humans and non-human primates have correlated frontal high-beta activity with the orienting of endogenous attention and shown the ability of the latter function to modulate visual performance. We here combined rhythmic transcranial magnetic stimulation (TMS) and diffusion imaging to study the relation between frontal oscillatory activity and visual performance, and we associated these phenomena to a specific set of white matter pathways that in humans subtend attentional processes. High-beta rhythmic activity on the right frontal eye field (FEF) was induced with TMS and its causal effects on a contrast sensitivity function were recorded to explore its ability to improve visual detection performance across different stimulus contrast levels. Our results show that frequency-specific activity patterns engaged in the right FEF have the ability to induce a leftward shift of the psychometric function. This increase in visual performance across different levels of stimulus contrast is likely mediated by a contrast gain mechanism. Interestingly, microstructural measures of white matter connectivity suggest a strong implication of right fronto-parietal connectivity linking the FEF and the intraparietal sulcus in propagating high-beta rhythmic signals across brain networks and subtending top-down frontal influences on visual performance.