Clinical implications of the causal relationship between insomnia and depression: how individually tailored treatment of sleeping difficulties could prevent the onset of depression.
Clinical implications of the causal relationship between insomnia and depression: how individually tailored treatment of sleeping difficulties could prevent the onset of depression.
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DOI：
10.1007/s13167-011-0079-9
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发表时间：
2011-09
期刊：
影响因子：
6.5
通讯作者：
Riemann, Dieter
中科院分区：
文献类型：
--
作者：
Baglioni, Chiara;Spiegelhalder, Kai;Nissen, Christoph;Riemann, Dieter
重度抑郁症通常与失眠症状同时发生。然而，可以解释这种关系的潜在心理生物学机制仍不清楚。过度兴奋和消极情绪被认为是可能的中介因素。多项研究表明，失眠可能是抑郁症的预测因素。我们小组最近进行的一项荟萃分析表明，与没有睡眠困难的人相比，失眠的人患抑郁症的风险是正常人的两倍。因此，通过识别有抑郁风险的人并提供个性化干预方案来改善个人结果，失眠的早期诊断和治疗至少可以部分预防未来抑郁的发展。需要对现有的治疗模块进行修改，在抑郁症的治疗中增加睡眠方案，在失眠的治疗中增加情感调节方案，提高失眠治疗的可及性，并制定生命早期的睡眠教育方案。
Major depression commonly co-occurs with symptoms of insomnia. However, the underlying psychobiological mechanisms which can explain this relationship are still not well understood. Hyperarousal and negative emotionality have been proposed to be possible mediating factors. Several studies have suggested that insomnia could be a predictor of depression. A recent meta-analysis conducted by our group showed that people with insomnia have a two-fold risk to develop depression, compared to people with no sleep difficulties. Thus, early diagnosis and treatment of insomnia could, at least partially, prevent the development of future depression, by identifying people at risk for depression and deliver personalized intervention protocols to improve individual outcome. Modifications of existing treatment modules are needed, as adding sleep protocols to the treatment of depression and affective regulation protocols to the treatment of insomnia, enhance the accessibility for the treatment of insomnia, and develop sleep education protocols in early periods of life.