Future Directions in Endometriosis Research and Therapeutics.
Future Directions in Endometriosis Research and Therapeutics.
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DOI：
10.2174/1573404813666161221164810
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发表时间：
2018-05
期刊：
影响因子：
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通讯作者：
W. Nothnick;Courtney A. Marsh;Zahraa Alali
中科院分区：
文献类型：
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作者：
W. Nothnick;Courtney A. Marsh;Zahraa Alali
背景子宫内膜异位症是一种常见于育龄期妇女的疾病，以疼痛、焦虑和不孕为特征。子宫内膜异位症是指子宫内膜组织在异位部位的生长，它仍然是一种神秘的疾病，目前的治疗方法并不理想。目前治疗的这些缺点大部分源于我们对疾病发病机制的不完全理解。一般认为子宫内膜异位症是一种雌激素依赖性疾病，因此，大多数治疗方法旨在减少雌激素的作用和/或产生。不幸的是，这种方法并不是对所有患有子宫内膜异位症的女性都有效，并且在那些成功使用它们的女性中，有可能产生健康副作用。目的总结目前子宫内膜异位症的治疗方法，探讨其局限性及治疗进展缓慢的原因。结果在本文中，我们总结了目前治疗子宫内膜异位症的方法，讨论了其局限性和缺乏进展的潜在原因，以更好的治疗这种疾病。结论基于目前的知识水平，在未来的研究中，在子宫内膜异位症的实验模型中评估潜在的子宫内膜异位症治疗方法，在基因组、miRNAome和蛋白质组水平上进行全面评估是非常必要的，同时也是整合临床相关终点的重要性。
Background Endometriosis is a disease common among women of reproductive age characterized by pain, anxiety and infertility. Defined as the growth of endometrial tissue in ectopic locations, endometriosis remains an enigmatic disease for which current treatments are less than ideal. Much of these shortcomings to current therapy stem from our incomplete understanding on the pathogenesis of the disease. It is generally accepted that endometriosis is an estrogen-dependent disease and, as such, the majority of treatment approaches aim at reducing estrogen action and/or production. Unfortunately, this approach is not effective in all women with endometriosis and in those women where success is achieved with their use, there is potential for health-comprising side effects. Objective The objective of this review is to summarize current approaches for treatment of endometriosis, discuss their limitations and potential reasons for lack of progress towards better therapeutics for this disease. Results In this review we summarize the current approaches for treatment of endometriosis, discuss their limitations and potential reasons for lack of progress towards better therapeutics for this disease. Conclusion Based upon the current state of knowledge, there is a strong necessity for through assessment at the level of the genome, miRNAome and proteome as well as the importance of integrating clinically-relevant endpoints in future studies which evaluate potential endometriosis therapies in experimental models of endometriosis.