Expression of nestin mRNA is a differentiation marker in thyroid tumors.
Expression of nestin mRNA is a differentiation marker in thyroid tumors.
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DOI：
10.1016/j.canlet.2009.02.006
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发表时间：
2009-07
期刊：
影响因子：
9.7
通讯作者：
Hiroya Yamada;T. Takano;Yasuhiro Ito;F. Matsuzuka;A. Miya;Kaoru Kobayashi;H. Yoshida;Mikio Watanabe;Y. Iwatani;A. Miyauchi
中科院分区：
文献类型：
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作者：
Hiroya Yamada;T. Takano;Yasuhiro Ito;F. Matsuzuka;A. Miya;Kaoru Kobayashi;H. Yoshida;Mikio Watanabe;Y. Iwatani;A. Miyauchi
巢蛋白是一种在某些成人组织中识别干细胞的标记物，其表达被认为与癌细胞的恶性程度有关。本研究应用实时定量逆转录-聚合酶链反应（RT-PCR）技术检测了不同类型甲状腺肿瘤中巢蛋白mRNA的表达水平。出乎意料的是，巢蛋白mRNA检测到几乎所有的分化型甲状腺肿瘤和正常甲状腺组织，而在未分化癌，这是最恶性的甲状腺滤泡细胞源性肿瘤中观察到的表达极低。提示nestin mRNA是一种分化标志物，其表达与甲状腺肿瘤的恶性程度无关。
Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.