Circulating osteoprotegerin is correlated with lipid profile, insulin sensitivity, adiponectin and sex steroids in an ageing male population
Circulating osteoprotegerin is correlated with lipid profile, insulin sensitivity, adiponectin and sex steroids in an ageing male population
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DOI：
10.1111/j.1365-2265.2006.02522.x
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发表时间：
2006-06-01
影响因子：
3.2
通讯作者：
Jambart, Selim
中科院分区：
文献类型：
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作者：
Gannage-Yared, Marie-Helene;Fares, Florence;Jambart, Selim
目的骨保护素（OPG）与血脂、胰岛素敏感性、脂肪细胞因子和性激素的关系研究较少，且存在争议。本研究的目的是在老年男性人群中观察OPG的相关性。设计151名非糖尿病的黎巴嫩老年男性方法：采用横断面研究的方法，对50-83岁的100例老年人进行血清OPG水平测定，并与临床指标进行相关性分析（年龄、腰围、体重指数（BMI）、收缩压和舒张压）以及代谢和激素参数。进行以下空腹实验室测量：血糖和胰岛素水平、总胆固醇、甘油三酯和HDL胆固醇、脂联素、瘦素以及性类固醇（睾酮、SHBG、游离雄激素指数、雌二醇、DHEAS）、GH和IGF-1。结果OPG水平与年龄显著相关（r = 0.28，P < 0.0001），与BMI、腰围、收缩压、舒张压无相关性。与代谢综合征受试者相比，无代谢综合征受试者的OPG水平有升高的趋势（3.58 +/- 1.28 vs. 3.26 +/- 1.04 pmol/l，P = 0.09）。OPG与空腹血糖、甘油三酯水平呈负相关与QUICKI指数呈正相关（r分别为-0.18，P = 0.031和-0.19，P = 0.02）（r = 0.17，P = 0.033）、高密度脂蛋白胆固醇（r = 0.21，P = 0.009）和脂联素（r = 0.27，P = 0.001）。与总胆固醇或低密度脂蛋白胆固醇水平以及瘦素水平无显著相关性。校正年龄因素后，OPG与甘油三酯（r =-0.19，P = 0.02）、血糖（r =-0.21，P = 0.011）和脂联素（r = 0.19，P = 0.02）仍有相关性。最后，OPG与SHBG呈正相关（r=0.31，P < 0.001），与游离雄激素指数呈负相关（r =-0.346，P < 0.001）;校正年龄后，两种相关性仍然存在（分别为r = 0-21，P = 0.009和r =-0.23，P = 0.005）。OPG与雌二醇水平无明显相关性，与DHEAS呈弱负相关（r =-0.18，P = 0.025）。此外，OPG和GH或IGF-1值之间没有发现显著相关性。多元逐步回归分析显示，OPG的主要影响因素是游离雄激素指数和脂联素（P分别< 0.0001和P = 0.015）。此外，第一次，OPG和脂联素之间的关联被描述。最后，我们发现OPG和游离雄激素指数之间的负相关性可能表明OPG在与衰老和性类固醇缺乏相关的心血管疾病增加中的潜在作用。
Objective The relationship between osteoprotegerin (OPG) and lipid profile, insulin sensitivity, adipocytokines and sex steroids has been poorly studied and subject to controversy. The purpose of this study was to look at the correlates of OPG in an elderly male population.Design One hundred and fifty-one nondiabetic, elderly Lebanese men (age range 50-83) were recruited in this cross-sectional study based on voluntary enrolment.Measurements In all the subjects, serum OPG levels were measured and related to clinical parameters (age, waist, body mass index (BMI), systolic and diastolic blood pressure), as well as to metabolic and hormonal parameters. The following fasting laboratory measurements were performed: plasma glucose and insulin levels, total cholesterol, triglycerides and HDL cholesterol, adiponectin, leptin, as well as sex steroids (testosterone, SHBG, free androgen index, ooestradiol, DHEAS), GH and IGF-1. QUICKI index was calculated as a measure of insulin sensitivity.Results OPG levels were significantly correlated with age (r = 0.28, P < 0.0001) but not with BMI, waist, systolic or diastolic blood pressure. There was a trend towards higher OPG levels in subjects without, compared to subjects with the metabolic syndrome (3.58 +/- 1.28 vs. 3.26 +/- 1.04 pmol/l, P = 0.09). OPG was negatively correlated with fasting glucose and triglyceride levels (r=-0-18, P = 0.031 and r = -0.19, P = 0.02, respectively) and positively correlated with the QUICKI index (r = 0.17, P = 0.033), HDL cholesterol (r = 0.21, P = 0.009) and adiponectin levels (r = 0.27, P = 0.001). No significant correlations were reported with total or LDL cholesterol levels and with leptin levels. After adjustment for age, OPG is still correlated with triglycerides (r = -0.19, P = 0.02), glucose (r = -0.21, P = 0.011) and adiponectin (r = 0.19, P = 0.02). Finally, OPG was positively associated with SHBG (r=0.31, P < 0.001) and negatively associated with free androgen index (r = -0.346, P < 0.001); both correlations persisted after adjustment for age (r = 0-21, P = 0.009 and r = -0.23, P = 0.005, respectively). No significant correlation was found between OPG and oestradiol levels while a weak negative correlation was demonstrated with DHEAS (r = -0.18, P = 0.025). Also, no significant correlation was found between OPG and GH or IGF-1 values. In a multiple regression analysis with a stepwise model, the main determinants of OPG were free androgen index and adiponectin (P < 0.0001 and P = 0.015, respectively).Conclusion Our results show that circulating OPG levels are favourably associated with some components of the metabolic syndrome. Also, for the first time, an association between OPG and adiponectin is described. Finally, the negative correlation we found between OPG and free androgen index may suggest a potential role of OPG in the increase in cardiovascular disease related to ageing and sex steroid deficiency.