Assessment of lung water distribution by nuclear magnetic resonance. A new method for quantifying and monitoring experimental lung injury.
Assessment of lung water distribution by nuclear magnetic resonance. A new method for quantifying and monitoring experimental lung injury.
复制标题
通过核磁共振评估肺水分布。
DOI：
10.1164/ajrccm/137.6.1371
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Akhtari,M
中科院分区：
文献类型：
--
作者：
Cutillo,AG;Morris,AH;Ailion,DC;Case,TA;Durney,CH;Ganesan,K;Watanabe,F;Akhtari,M
我们开发了一种新的分析方法，使用核磁共振（NMR）成像数据来量化肺水的含量和分布。这种新方法生成了肺水密度的分布，其中对应于给定水密度的体素比例在纵轴上绘制为水密度在横轴上的函数，从而补充了核磁共振图像提供的空间信息。我们在正常切除的肺和完整的活大鼠的肺容量相当的情况下获得了可重复的肺水分布数据。在正常切除的未灌注大鼠肺中，其分布随充气程度而变化，但与肺水肿相关的变化相比，变化较小。经支气管灌注生理盐水、静脉注射油酸、快速静脉输注生理盐水诱导肺水肿后，肺水密度分布发生明显变化。肺水密度分布数据与重量法肺水测量值具有良好的相关性（切除肺相关系数为0.948，活鼠为0.823）。新的分析方法是非侵入性的，提供了容易重复的测量，并且对肺水变化的灵敏度与重量技术一样高。
We have developed a new analytical method that uses nuclear magnetic resonance (NMR) imaging data to quantify lung water content and distribution. This new method generates a distribution of lung water density in which the fraction of voxels corresponding to a given water density is plotted on the vertical axis as a function of water density on the horizontal axis, thereby complementing the spatial information provided by the NMR image. We obtained reproducible lung water distribution data at comparable lung volumes in normal excised lungs and in intact living rats. In normal excised unperfused rat lungs, the distribution varied with the degree of inflation, but the changes were small compared with those associated with lung edema. The lung water density distribution changed markedly after induction of lung edema by intrabronchial saline instillation, intravenous oleic acid injection, and rapid intravenous saline infusion. Lung water density distribution data were well correlated (correlation coefficient = 0.948 for the excised lungs and 0.823 for the intact living rats) with gravimetric lung water measurements. The new analytical method is noninvasive, provides easily repeatable measurements, and is as sensitive as the gravimetric technique to lung water changes.