CLIC1 overexpression is associated with poor prognosis in gallbladder cancer
CLIC1 overexpression is associated with poor prognosis in gallbladder cancer
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CLIC1 过度表达与胆囊癌的不良预后相关。
DOI：
10.1007/s13277-014-2606-5
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Liu, Yingbin
中科院分区：
文献类型：
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作者：
Ding, Qichen;Li, Maolan;Liu, Yingbin
细胞内氯离子通道1（CLIC 1）基因家族是最近发现的一类氯离子通道蛋白。虽然CLIC 1参与在一些癌症如胃癌和结肠癌中已被充分确立，但其在胆囊癌（GBC）中的表达模式仍然未知。本研究的目的是探讨CLIC 1的表达与胆囊癌的进展和预后的关系。八个新鲜胆囊癌配对与相邻的非肿瘤组织进行定量使用实时PCR和蛋白质印迹。通过免疫组织化学染色评价来自切除的胆囊癌（n=75）和胆石症（n=75）的组织样品的CLIC 1表达。它们的表达与不同的临床病理参数相关。CLIC 1在胆囊癌中的表达（62.7%）明显高于胆石症（21.3%，p
The chloride intracellular channel 1 (CLIC1) gene family is a recently identified class of Cl channel proteins. Although CLIC1 involvement is well established in some cancers such as gastric cancer and colon cancer, its expression pattern in gallbladder cancer (GBC) remains unknown. The aimof our study was to investigate the expression of CLIC1 in relation to progression and prognosis of GBC. Eight fresh gallbladder cancers paired with adjacent non-tumour tissues were quantified using real-time PCR and Western blot. Tissue samples from resected gallbladder cancer (n=75) and cholelithiasis (n=75) were evaluated for CLIC1 expression by immunohistochemical staining. Their expression was correlated with different clinicopathological parameters. CLIC1 expression was significantly higher (62.7 %) in gallbladder cancer than in cholelithiasis (21.3 %, p