CYSTOMETRY IN MICE - INFLUENCE OF BLADDER FILLING RATE AND CIRCADIAN VARIATIONS IN BLADDER COMPLIANCE
CYSTOMETRY IN MICE - INFLUENCE OF BLADDER FILLING RATE AND CIRCADIAN VARIATIONS IN BLADDER COMPLIANCE
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DOI：
10.1016/s0022-5347(17)36549-7
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发表时间：
1992-07-01
影响因子：
6.6
通讯作者：
DORR, W
中科院分区：
文献类型：
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作者：
DORR, W
要对实验动物的膀胱测量进行有意义的解释，需要对可能影响结果的因素进行详细分析。在本研究中，详细研究了导管大小和膀胱充盈率的影响，并通过膀胱测压评价了(天)时间对小鼠膀胱顺应性的影响。外径分别为0.6和0.8毫米的套管。导管越大，漏气压力越大，漏气量越大。充盈率高于0.1ml/min时，无论是储存量还是膀胱壁阻力都不存在依赖性。充盈率低于TH时，随着充盈率的降低，膀胱容量增加，壁阻减小。此外，泄漏最终发生在20毫米以下。HG充盈率较低。观察到膀胱顺应性和壁阻有明显的昼夜变化。最大存储容量出现在晚上7点。水库功能随后在凌晨1点之间降至平台期。和下午1点
Meaningful interpretation of cystometric measurements in experimental animals requires detailed analysis of factors that could affect the results. In the present study, the effect of catheter size and bladder filling rate were studied in detail; in addition, the influence of (day) time on bladder compliance was assessed by cystometry in mice.Bladder reservoir function was independent of the catheter size, when i.v. cannulae with outer diameters of 0.6 and 0.8 mm. were used, but leakage pressure and leakage volume were increased with the larger catheter. Neither the storage capacity nor the bladder wall resistance showed dependence on filling rates above 0.1 ml./min. Below th's rate, bladder capacity increased and wall resistance decreased with decreasing filling rate. Furthermore, leakage eventually occurred below 20 mm. Hg with the lower filling rates.Marked diurnal variations in bladder compliance and wall resistance were observed. Maximum storage capacity was observed at 7 p.m. and the reservoir function subsequently decreased to a plateau between 1 a.m. and 1 p.m.