Synergistic antibacterial attributes of copper-doped polydopamine nanoparticles: an insight into photothermal enhanced antibacterial efficacy
Synergistic antibacterial attributes of copper-doped polydopamine nanoparticles: an insight into photothermal enhanced antibacterial efficacy
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DOI：
10.1088/1361-6528/ad19ad
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发表时间：
2024-04-08
期刊：
影响因子：
3.5
通讯作者：
Chen，Peixing
中科院分区：
文献类型：
--
作者：
Hu，Zhiqiong;Wu，Kexian;Chen，Peixing
耐抗生素细菌及其相关传染病对人类健康构成严重威胁。金属纳米颗粒的抗菌活性已广泛应用于多种生物医学领域，表明其能有效抑制多种细菌的生长。在本研究中，以去离子水和乙醇为溶剂，通过经济的方法合成了铜掺杂的聚多巴胺纳米粒子（Cu@ PDA NPs）。利用聚多巴胺纳米粒子（PDA NPs）光热转换效率高和铜离子固有的抗菌特性，设计了具有增强抗菌特性的纳米粒子。与PDA NPs相比，Cu@ PDA NPs具有更粗糙的表面和更高的zeta电位，并且两者都具有显着的光热转换效率。综合抗菌评价证实了Cu@ PDA NPs由于其含铜量而具有优越的抗菌效果。这些易于制备的纳米抗菌材料由于其光热和光谱抗菌特性的协同结合，在感染预防和治疗方面具有巨大的潜力。
Antibiotic-resistant bacteria and associated infectious diseases pose a grave threat to human health. The antibacterial activity of metal nanoparticles has been extensively utilized in several biomedical applications, showing that they can effectively inhibit the growth of various bacteria. In this research, copper-doped polydopamine nanoparticles (Cu@ PDA NPs) were synthesized through an economical process employing deionized water and ethanol as a solvent. By harnessing the high photothermal conversion efficiency of polydopamine nanoparticles (PDA NPs) and the inherent antibacterial attributes of copper ions, we engineered nanoparticles with enhanced antibacterial characteristics. Cu@ PDA NPs exhibited a rougher surface and a higher zeta potential in comparison to PDA NPs, and both demonstrated remarkable photothermal conversion efficiency. Comprehensive antibacterial evaluations substantiated the superior efficacy of Cu@ PDA NPs attributable to their copper content. These readily prepared nano-antibacterial materials exhibit substantial potential in infection prevention and treatment, owing to their synergistic combination of photothermal and spectral antibacterial features.