Borneol-modified chitosan: Antimicrobial adhesion properties and application in skin flora protection
Borneol-modified chitosan: Antimicrobial adhesion properties and application in skin flora protection
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冰片改性壳聚糖：抗菌粘附特性及其在皮肤菌群保护中的应用
DOI：
10.1016/j.carbpol.2019.115378
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发表时间：
2019
影响因子：
11.2
通讯作者：
Wang Xing
中科院分区：
文献类型：
--
作者：
Xin Yu;Zhao Hongjuan;Xu Jiangqi;Xie Zixu;Li Guofeng;Gan Zhihua;Wang Xing
壳聚糖的抗菌改性通常赋予产物较强的杀菌活性。但如果产品与人体皮肤直接接触，对人体健康有益的皮肤植物群可能会受到破坏。为了解决这个问题，我们开发了一种立体化学的抗菌策略，通过使用稳定的席夫碱键将β-4-甲酰苯甲酸酯接枝到壳聚糖上;这个过程产生了一种新型的抗菌材料--β-羟基改性壳聚糖（BMC）。用革兰氏阴性大肠杆菌、革兰氏阳性枯草芽孢杆菌和尼日尔曲霉对该材料进行挑战。所有测试均显示出优异的抗微生物粘合性能。豚鼠皮肤实验进一步证明BMC不损害皮肤植物群。由于立体化学的抗菌机制，BMC成功地抵御了病原菌，保护了皮肤植物群。因此，这种材料可能在多功能纺织品、医疗保健和柔性皮肤电子产品中具有良好的潜在应用。
Antimicrobial modifications of chitosan usually endow the products with strong bactericidal activities. However, if the products come into direct contact with human skin, the skin flora, which is beneficial to human health, may be damaged. To address this issue, we developed a stereochemical antimicrobial strategy by grafting borneol 4-formylbenzoate to chitosan using a stable Schiff base bond; this process yielded borneol-modified chitosan (BMC) as a novel antimicrobial material. This material was challenged with gram-negativeEscherichia coli, gram-positiveBacillus subtilis, andAspergillus niger. All tests showed excellent antimicrobial adhesive properties. Guinea pig skin experiments further demonstrated that BMC did not damage the skin flora. Owing to the antimicrobial mechanism of borneol stereochemistry, BMC successfully defended against pathogens and protected the skin flora. Thus, this material may have excellent potential applications in multifunctional textiles, healthcare, and flexible skin electronics.