A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX
A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX
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真菌 ABC 转运蛋白 FgAtm1 通过转录因子级联 FgAreA-HapX 调节铁稳态
DOI：
10.1371/journal.ppat.1007791
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发表时间：
2019-09
期刊：
影响因子：
6.7
通讯作者：
Yin Yanni
中科院分区：
文献类型：
--
作者：
Wang Zhihui;Ma Tianling;Huang Yunyan;Wang Jing;Chen Yun;Kistler H Corby;Ma Zhonghua;Yin Yanni
Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown. Here, we found that one ABC transporter (named FgAtm1) is involved in regulating iron homeostasis, by screening sensitivity to iron stress for 60 ABC transporter mutants of Fusarium graminearum, a devastating fungal pathogen of small grain cereal crops worldwide. The lack of FgAtm1 reduces the activity of cytosolic Fe-S proteins nitrite reductase and xanthine dehydrogenase, which causes high expression of FgHapX via activating transcription factor FgAreA. FgHapX represses transcription of genes for iron-consuming proteins directly but activates genes for iron acquisition proteins by suppressing another iron regulator FgSreA. In addition, the transcriptional activity of FgHapX is regulated by the monothiol glutaredoxin FgGrx4. Furthermore, the phosphorylation of FgHapX, mediated by the Ser/Thr kinase FgYak1, is required for its functions in iron homeostasis. Taken together, this study uncovers a novel regulatory mechanism of iron homeostasis mediated by an ABC transporter in an important pathogenic fungus.
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影响因子：
30.3
作者：
Chen C;Pande K;French SD;Tuch BB;Noble SM
通讯作者：
Noble SM
影响因子：
2.5
作者：
Giese, Henriette;Sondergaard, Teis Esben;Sorensen, Jens Laurids
通讯作者：
Sorensen, Jens Laurids
DOI：
10.1039/c3cc48239a
发表时间：
2014-04-14
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Qi W;Li J;Cowan JA
通讯作者：
Cowan JA
影响因子：
2.9
作者：
Miao R;Kim H;Koppolu UM;Ellis EA;Scott RA;Lindahl PA
通讯作者：
Lindahl PA
影响因子：
14.8
作者：
Saleh, Abdelaty;Alvarez-Venegas, Raul;Avramova, Zoya
通讯作者：
Avramova, Zoya