Local tissue complement synthesis--fine tuning a blunt instrument.
Local tissue complement synthesis--fine tuning a blunt instrument.
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DOI：
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发表时间：
2001
影响因子：
3.2
通讯作者：
J. Marsh;W. Zhou;S. Sacks
中科院分区：
文献类型：
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作者：
J. Marsh;W. Zhou;S. Sacks
补体对宿主防御和炎症调节具有重要作用。肝脏是循环补体的主要来源。然而，许多其他器官能够以受调节的组织特异性方式合成部分或全部补体成分。越来越多的证据表明，这种局部产生的补体具有生物活性，并在局部环境中发挥强大的作用。我们回顾了局部补体合成在不同器官中的作用，并推测其对免疫和代谢功能的影响。
Complement is important to host defense and the regulation of inflammation. The liver is overwhelmingly the major source of circulating complement. However, many other organs are capable of synthesizing some or all of the complement components in a regulated tissue-specific manner. There is increasing evidence that this locally generated complement is biologically active and exerts powerful effects within the local environment. We review the role of local complement synthesis within different organs and speculate on its implication for immune and metabolic functions.