State-Dependent Performance of Optic-Flow Processing Interneurons
State-Dependent Performance of Optic-Flow Processing Interneurons
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DOI：
10.1152/jn.00395.2009
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发表时间：
2009-12-01
影响因子：
2.5
通讯作者：
Krapp, Holger G.
中科院分区：
文献类型：
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作者：
Longden, Kit D.;Krapp, Holger G.
Longden KD，Krapp HG.光流处理中间神经元的状态依赖性能。J Neurophysiol 102：3606-3618，2009.首次发表于2009年10月7日; doi：10.1152/jn.00395.2009。主动运动状态在代谢上是昂贵的，并且需要有效的感觉处理，以避免浪费的运动并科普感官刺激的扩展带宽。这对于飞行动物来说尤其如此，因为飞行，而不是步行或休息，会使新陈代谢呈阶梯状增加，以精确执行和控制运动。感觉处理本身具有显著的代谢成本，但是感觉处理对不同运动状态的调节的原理还没有被很好地理解。我们使用的绿头苍蝇作为一个模型系统来研究视觉处理的神经调节剂，章鱼胺，这是已知的参与飞行生理的调节的影响。我们应用章鱼胺激动剂，并记录了已知处理定向运动刺激的自发诱导光流的识别视觉中间神经元的定向运动反应。这些神经元的神经反应范围增加，反应潜伏期缩短。我们还发现，由于自发峰电位率升高，细胞的负信号范围增加。同时，细胞编码的首选自运动参数与状态无关。我们的研究结果表明，在丽蝇大力昂贵的感觉编码策略，如快速，大的反应，和高自发的尖峰活动可以调整的神经调节剂章鱼胺，可能会节省能源在安静的运动状态。
Longden KD, Krapp HG. State-dependent performance of optic-flow processing interneurons. J Neurophysiol 102: 3606-3618, 2009. First published October 7, 2009; doi:10.1152/jn.00395.2009. Active locomotive states are metabolically expensive and require efficient sensory processing both to avoid wasteful movements and to cope with an extended bandwidth of sensory stimuli. This is particularly true for flying animals because flight, as opposed to walking or resting, imposes a steplike increase in metabolism for the precise execution and control of movements. Sensory processing itself carries a significant metabolic cost, but the principles governing the adjustment of sensory processing to different locomotor states are not well understood. We use the blowfly as a model system to study the impact on visual processing of a neuromodulator, octopamine, which is known to be involved in the regulation of flight physiology. We applied an octopamine agonist and recorded the directional motion responses of identified visual interneurons known to process self-motion-induced optic flow to directional motion stimuli. The neural response range of these neurons is increased and the response latency is reduced. We also found that, due to an elevated spontaneous spike rate, the cells' negative signaling range is increased. Meanwhile, the preferred self-motion parameters the cells encode were state independent. Our results indicate that in the blowfly energetically expensive sensory coding strategies, such as rapid, large responses, and high spontaneous spike activity could be adjusted by the neuromodulator octopamine, likely to save energy during quiet locomotor states.