Cerebrovascular Complications of COVID-19
Cerebrovascular Complications of COVID-19
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DOI：
10.1161/strokeaha.120.031265
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发表时间：
2020-09-01
期刊：
影响因子：
8.3
通讯作者：
Azhar, Salman
中科院分区：
文献类型：
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作者：
Katz, Jeffrey M.;Libman, Richard B.;Azhar, Salman
背景与目的：2019冠状病毒病（COVID-19）迅速演变为全球大流行，并伴有包括中风在内的多种系统性并发症。我们报道了迄今为止最大的COVID-19脑血管并发症病例系列，并与未感染的脑卒中患者进行了比较。方法：对2020年3月14日至4月26日期间在纽约11家医院接受影像确诊的COVID-19卒中患者进行回顾性病例系列研究。收集了人口统计学、临床、实验室、影像学和结局数据，并将病例与1年前无COVID-19的日期匹配的对照组进行了比较。结果：共发现新冠肺炎阳性脑卒中86例（平均年龄67.4岁，女性44.2%）。缺血性中风（83.7%）和非局灶性神经表现（67.4%）占主导地位，通常涉及多血管分布（45.8%）并伴有出血（20.8%）。与对照组（n=499）相比，COVID-19与院内卒中发病相关(47.7%对5.0%
Background and Purpose: Coronavirus disease 2019 (COVID-19) evolved quickly into a global pandemic with myriad systemic complications, including stroke. We report the largest case series to date of cerebrovascular complications of COVID-19 and compare with stroke patients without infection. Methods: Retrospective case series of COVID-19 patients with imaging-confirmed stroke, treated at 11 hospitals in New York, between March 14 and April 26, 2020. Demographic, clinical, laboratory, imaging, and outcome data were collected, and cases were compared with date-matched controls without COVID-19 from 1 year prior. Results: Eighty-six COVID-19-positive stroke cases were identified (mean age, 67.4 years; 44.2% women). Ischemic stroke (83.7%) and nonfocal neurological presentations (67.4%) predominated, commonly involving multivascular distributions (45.8%) with associated hemorrhage (20.8%). Compared with controls (n=499), COVID-19 was associated with in-hospital stroke onset (47.7% versus 5.0%;P