Homeodomain proteins and the regulation of gene expression
Homeodomain proteins and the regulation of gene expression
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DOI：
10.1016/0955-0674(90)90132-x
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发表时间：
1990-06-01
影响因子：
7.5
通讯作者：
Gehring, W. J.
中科院分区：
文献类型：
--
作者：
Affolter, M.;Schier, A.;Gehring, W. J.
同源盒（HB）是一个180 bp的DNA序列元件，首次被发现是同源基因与其他控制Drasc@ ih发育的基因之间的序列相似性区域（McGinnis et al . Nature 1984, 308: 428-433; Scott and Weiner, Proc NatlAcudSci CBA 1984, 81: 411H119）。现在已经在真核生物（从酵母到人）中发现了HB基因的许多拷贝（Gehring, Science 1987, 236: 1245-1252； Scott等人，Biocbim Bioplys学报1989,989:25-48）。HI3是这些基因编码序列的一部分，它编码的60个氨基酸被称为同源结构域（HD）。现在越来越多的证据表明，I-ID蛋白是一种转录因子，HD在其中部分或全部负责DNA的序列特异性识别。在这篇综述中，我们将描述一些特定的I-ID或I-ID蛋白的结构和功能特性。然后，我们将重点关注具有良好特征的I-ID蛋白调节其靶基因表达的分子机制，并在高等真核生物发育途径中涉及众多I-ID蛋白的情况下讨论这些例子。
The homeobox (HB), a 180 bp DNA sequence element, was first identified as a region of sequence similarity between homeotic genes and several other genes involved in the control of Drasc@ ih development (McGinnis et al, Nature 1984, 308: 428-433; Scott and Weiner, Proc NatlAcudSci CBA 1984, 81: 411H119). HB genes have now been found in numerous copies in eukaryotic organisms ranging from yeast to man (Gehring, Science 1987, 236: 1245-1252; Scott et al, Biocbim Bioplys Acta 1989, 989: 25-48). The HI3 is part of the coding sequence of these genes and the 60 amino acids it encodes are referred to as the homeodomain (HD). Evidence is now accumulating that I-ID proteins are transcription factors in which the HD is partly or fully responsible for sequencespecific recognition of DNA.In this review, we will describe some of the structural and functional properties of speciiic I-IDS or I-ID proteins. We will then focus on the molecular mechanisms by which well characterized I-ID proteins regulate the expression of their target genes and discuss these examples in the light of the involvement of numerous I-ID proteins in developmental pathways in higher eukaryotes.