Comparative assessment of experimental myocardial infarction with 99Tcm-hexakis‐tbutyl-isonitrile (sestamibi), 111In‐antimyosin and 201T1
Comparative assessment of experimental myocardial infarction with 99Tcm-hexakis‐tbutyl-isonitrile (sestamibi), 111In‐antimyosin and 201T1
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99Tcm-六叔丁基异腈（塞他米比）、111In-抗肌球蛋白和 201T1 对实验性心肌梗死的比较评估
DOI：
10.1097/00006231-199110000-00004
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发表时间：
1991
影响因子：
1.5
通讯作者：
S. Mousa
中科院分区：
文献类型：
--
作者：
B. Khaw;S. Mousa
单阳离子99 Tcm-六甲氧基-2-甲基丙基异腈（99 Tcm-sestamibi）是一种心肌灌注标记物，对缺血性心脏病的诊断具有潜在的临床价值。将该化合物在家兔实验性心肌梗死中的动力学与持续性左前降支（LAD）冠状动脉闭塞24 h时111 In-抗肌球蛋白Fab和201 T1的分布进行比较。梗塞区111 In-抗肌球蛋白的最大摄取量高达0.34%注射剂量/克（i.d.）。g ~（-1），而正常心肌活性仅为0. 045% i.d. g-1。正常心肌最大~（201）T_1和~（99）Tcm-甲氧基异丁基异腈摄取分别为0.16和0.14%。G-1，分别。由于其更快的血液清除率，99 Tcm-甲氧基异丁基异腈和201 T1能够早期描绘放射性示踪剂分布缺陷的区域。111 In-抗肌球蛋白需要较长的循环时间，因为体内梗死可视化较慢的血液清除。数据还表明，在兔持续性LAD闭塞性梗死中，相对于抗肌球蛋白定位（肌细胞坏死的指标），sestamibi和201 T1的反向分布没有显著差异（I/Nsestamibi = 0.213 I/N（AM）+ 115.7，r = 0.91，和I/N = 0.181 I/N（AM）+ 114.4，r = 0.89）。
The monocationic 99Tcm-hexakis-2-methoxy-2-methyl propyl isonitrile (99Tcm-sestamibi) is a myocardial perfusion marker with potential clinical value in the diagnosis of ischaemic heart disease. The kinetics of this compound in experimental myocardial infarction in rabbits was compared to the distributions of 111In-antimyosin Fab and 201T1 at 24 h of persistent left anterior descending (LAD) coronary artery occlusion. The maximum uptake of 111In-antimyosin in the infarct was as high as 0.34% injected dose per gram (i.d. g-1), whereas normal myocardial activity was only 0.045% i.d. g--1. Maximal 201T1 and 99Tcm-sestamibi uptakes in normal myocardium were 0.16 and 0.14% i.d. g-1, respectively. Because of their faster blood clearances, 99Tcm-sestamibi and 201T1 were able to delineate regions of radiotracer distribution defects early. 111In-antimyosin required a longer circulation time for in vivo infarct visualization because of slower blood clearance. The data also demonstrated that in persistent LAD occlusion infarction in rabbits, the inverse distribution of sestamibi and 201T1 relative to antimyosin localization (indicator of myocyte necrosis) is not significantly different (I/Nsestamibi = 0.213 I/N(AM) + 115.7, r = 0.91, and I/N = 0.181 I/N(AM) + 114.4, r = 0.89).