CLASSES AND MECHANISMS OF CALCIUM WAVES
CLASSES AND MECHANISMS OF CALCIUM WAVES
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DOI：
10.1016/0143-4160(93)90099-r
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发表时间：
1993-11-01
期刊：
影响因子：
4
通讯作者：
JAFFE, LF
中科院分区：
文献类型：
--
作者：
JAFFE, LF
最著名的钙波的移动速度约为5-30微米/S(20摄氏度)，称为快波，以区别于慢(收缩)波，慢(收缩)波的移动速度为0.1-1微米/S，以及电传播的超快波。快波在细胞内深入，似乎构成了大多数钙信号的基础。它们的速度和机制在所有或几乎所有真核细胞中都是非常保守的。在各种完全活跃(但不过度刺激)的细胞中，它们的平均速度在20摄氏度下约15-30微米/S之间。它们的幅度通常在3-30微米之间，频率在每10-300 S一个之间。它们是由路德方程控制的反应扩散机制传播的，在路德方程中，钙离子是唯一的扩散传播子，钙诱导钙释放是唯一的反应，尽管这个反应跨越了通常受IP3或cADPR调节的各种通道。然而，它们通常可能由第二种腔模式的CICR启动，该模式发生在内质网内。此外，它们通过各种机制在细胞间传播。另一方面，缓慢的细胞内波可能通过拉伸敏感的钙通道机械地传播。
The best known calcium waves move at about 5-30 mum/s (art 20-degrees-C) and will be called fast waves to distinguish them from slow (contractile) ones which move at 0.1-1 mum/s as well as electrically propagated, ultrafast ones. Fast waves move deep within cells and seem to underlie most calcium signals. Their velocity and hence mechanism has been remarkably conserved among all or almost all eukaryotic cells. In fully active (but not overstimulated) cells of all sorts, their mean speeds lie between about 15-30 mum/s at 20-degrees-C. Their amplitudes usually lie between 3-30 muM and their frequencies from one per 10-300 s. They are propagated by a reaction diffusion mechanism governed by the Luther equation in which Ca ions are the only diffusing propagators, and calcium induced calcium release, or CICR, the only reaction; although this reaction traverses various channels which are generally modulated by IP3 or cADPR. However, they may be generally initiated by a second, lumenal mode of CICR which occurs within the ER. Moreover, they are propagated between cells by a variety of mechanisms. Slow intracellular waves, on the other hand, may be mechanically propagated via stretch sensitive calcium channels.