SYNTHETIC PENTAPEPTIDE WITH BIOLOGICAL-ACTIVITY CHARACTERISTIC OF THE THYMIC HORMONE THYMOPOIETIN
SYNTHETIC PENTAPEPTIDE WITH BIOLOGICAL-ACTIVITY CHARACTERISTIC OF THE THYMIC HORMONE THYMOPOIETIN
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DOI：
10.1126/science.451537
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发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
VANWAUWE, J
中科院分区：
文献类型：
--
作者：
GOLDSTEIN, G;SCHEID, MP;VANWAUWE, J
合成了胸腺生成素第32-36位氨基酸残基的五肽-N-乙酰-赖氨酰-N-乙酰-缬氨酰-酪氨酸。在体外，该五肽诱导小鼠原胸腺细胞分化为胸腺细胞，并抑制B [骨髓衍生]谱系细胞的分化诱导。这种作用的组合对于母体分子胸腺生成素是独特的。在体内，五肽减少了正常情况下存在于无胸腺小鼠脾脏中的大量自体玫瑰花结形成细胞。这也是胸腺生成素的一个特性。容易合成的五肽显然对应于胸腺生成素的活性位点，并可作为胸腺生成素的治疗替代品。
The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32-36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B [bone marrow-derived] lineage. This combination of actions is unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice. This also is a property of thymopoietin. The readily synthesized pentapeptide apparently corresponds to an active site of thymopoietin and may serve as a therapeutic substitute for thymopoietin.