pH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy
pH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy
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DOI：
10.1016/j.biomaterials.2014.03.046
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发表时间：
2014-07-01
期刊：
影响因子：
14
通讯作者：
Lo, Chun-Liang
中科院分区：
文献类型：
--
作者：
Chiang, Yi-Ting;Lo, Chun-Liang
本研究提出了一种肿瘤细胞外基质pH诱导靶向脂质体（ECM靶向脂质体），由甲氧基-聚（乙二醇）-b-聚（N-2-羟丙基甲基丙烯酰胺-共-组氨酸）-胆固醇共聚物和生物素2-聚乙二醇交联剂通过氢键交联，以克服脂质体的缺陷。本研究对靶向脂质体的pH响应性、药物释放行为、抗癌效率、时间依赖性器官分布和毒性效应进行了全面的研究。实验结果表明，ECM靶向脂质体在酸性条件下具有快速释药特性。由于ECM靶向脂质体优先在肿瘤中蓄积，因此具有优异的体内抗癌活性和较低的肝、肾毒性。靶向肿瘤细胞外基质的脂质体具有靶向肿瘤细胞外基质的能力，在抗肿瘤治疗中具有潜在的应用前景。(C)2014爱思唯尔有限公司版权所有。
This study presents a tumor-extracellular matrix pH-induced targeting liposome (ECM-targeting liposomes), crosslinked from methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymers and biotin2-polyethylene glycol crosslinkers by hydrogen bonds to overcome the defects of liposomes. In this study, ECM-targeting liposomes were completely investigated their pH-responsibility, drug releasing behaviors, anticancer efficiencies and the time-dependent organ distribution and toxic effects. Experimental results indicate that ECM-targeting liposomes showed rapid drug releasing profiles in acidic conditions. Because the ECM-targeting liposomes accumulated preferentially in tumor, the ECM-targeting liposomes exhibited exceptional anticancer activity in vivo and lower hepatic and renal toxicity. The ECM-targeting liposomes which are switched on the targeting ability in tumor ECM possess potential for future application in anticancer therapy. (C) 2014 Elsevier Ltd. All rights reserved.