Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.
Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.
复制标题
父母接触四氢大麻酚会导致下一代强迫性地寻求海洛因并改变纹状体突触可塑性。
DOI：
10.1038/npp.2013.352
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Hurd,YasminL
中科院分区：
文献类型：
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作者：
Szutorisz,Henrietta;DiNieri,JenniferA;Sweet,Eric;Egervari,Gabor;Michaelides,Michael;Carter,JennaM;Ren,Yanhua;Miller,MichaelL;Blitzer,RobertD;Hurd,YasminL
Recent attention has been focused on the long-term impact of cannabis exposure, for which experimental animal studies have validated causal relationships between neurobiological and behavioral alterations during the individual’s lifetime. Here, we show that adolescent exposure to Δ 9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, results in behavioral and neurobiological abnormalities in the subsequent generation of rats as a consequence of parental germline exposure to the drug. Adult F1 offspring that were themselves unexposed to THC displayed increased work effort to self-administer heroin, with enhanced stereotyped behaviors during the period of acute heroin withdrawal. On the molecular level, parental THC exposure was associated with changes in the mRNA expression of cannabinoid, dopamine, and glutamatergic receptor genes in the striatum, a key component of the neuronal circuitry mediating compulsive behaviors and reward sensitivity. Specifically, decreased mRNA and protein levels, as well as NMDA receptor binding were observed in the dorsal striatum of adult offspring as a consequence of germline THC exposure. Electrophysiologically, plasticity was altered at excitatory synapses of the striatal circuitry that is known to mediate compulsive and goal-directed behaviors. These findings demonstrate that parental history of germline THC exposure affects the molecular characteristics of the striatum, can impact offspring phenotype, and could possibly confer enhanced risk for psychiatric disorders in the subsequent generation.
