A Novel Class of RIP1/RIP3 Dual Inhibitors
A Novel Class of RIP1/RIP3 Dual Inhibitors
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DOI：
10.33696/2689-2812.2.013
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Ting Zhou;Bo Liu
中科院分区：
文献类型：
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作者：
Ting Zhou;Bo Liu
Necroptosis is a form of programed necrosis mediated by receptor-interacting serine/ threonine-protein kinase 1 (RIP1) and RIP3 and the subsequent phosphorylation of mixed lineage kinase domain-like protein (MLKL) [1–4]. Necroptosis has been implicated in multiple human diseases such as myocardial infarction, atherosclerosis, and abdominal aortic aneurysms (AAAs). Levels of RIP3 are elevated in the human tissues affected by these diseases. Furthermore, mice deficient of the gene encoding RIP3 are protected from disease in preclinical models [5–8].
