Birth characteristics and female sex hormone concentrations during adolescence: results from the Dietary Intervention Study in Children.
Birth characteristics and female sex hormone concentrations during adolescence: results from the Dietary Intervention Study in Children.
复制标题
青春期的出生特征和女性性激素浓度：儿童饮食干预研究的结果。
DOI：
10.1007/s10552-011-9734-7
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Dorgan,JoanneF
中科院分区：
文献类型：
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作者：
Ruder,ElizabethH;Hartman,TerrylJ;Rovine,MichaelJ;Dorgan,JoanneF
背景出生特征和成人激素浓度影响乳腺癌的风险，但很少有人知道出生特征对激素浓度的影响，特别是在青春期。（出生体重，出生身长，孕龄）在儿童饮食干预研究中，278名女性参与者在儿童晚期和青春期的血清性激素浓度。重复测量方差分析模型被用来评估出生特征和血清雌激素和雄激素在5个不同时间点的关系，平均7 years.ResultsIn分析，没有考虑到从抽血到月经初潮的时间，出生体重与月经初潮前雌二醇，硫酸雌酮，雄烯二酮，睾酮，和硫酸脱氢表雄酮（DHEAS）。在月经初潮后的分析中，出生体重与研究中的任何激素浓度均无显著相关性。出生时长和胎龄与激素浓度之前或之后menarche.ConclusionBirth体重呈负相关性激素浓度在模型月经初潮前未调整的时间从抽血，直到menarche.ImpactThe在子宫内的环境有长期的影响激素环境，这可能会导致乳腺癌的风险。
BackgroundBirth characteristics and adult hormone concentrations influence breast cancer risk, but little is known about the influence of birth characteristics on hormone concentrations, particularly during adolescence.MethodsWe evaluated the association of birth characteristics (birth weight, birth length, and gestational age) with serum sex hormone concentrations during late childhood and adolescence in 278 female participants of the Dietary Intervention Study in Children. Repeated measures analysis of variance models were used to assess the relationships of birth characteristics and serum estrogens and androgens at five different time points over a mean period of 7 years.ResultsIn analyses that did not take into account time from blood draw until menarche, birth weight was inversely associated with pre-menarche concentrations of estradiol, estrone sulfate, androstenedione, testosterone, and dehydroepiandrosterone sulfate (DHEAS). In the post-menarche analyses, birth weight was not significantly associated with concentration of any of the hormones under investigation. Birth length and gestational age were not associated with hormone concentrations before or after menarche.ConclusionBirth weight is inversely associated with sex hormone concentrations before menarche in the model unadjusted for time from blood draw until menarche.ImpactThe in utero environment has long-term influences on the hormonal milieu, which could potentially contribute to breast cancer risk.