The Depot-Form of Glucocorticoid Decreases Cortisol but not ACTH and Beta-Endorphin Levels in Human Plasma
The Depot-Form of Glucocorticoid Decreases Cortisol but not ACTH and Beta-Endorphin Levels in Human Plasma
复制标题
糖皮质激素的长效制剂可降低人血浆中的皮质醇水平，但不会降低促肾上腺皮质激素和β-内啡肽水平
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Z. Wasek
中科院分区：
文献类型：
--
作者：
A. Łypka;J. Łazowski;A. Szczudlik;Z. Wasek
虽然外源性糖皮质激素对下丘脑-垂体-肾上腺轴的抑制作用早已为人们所知，但这种作用的部位和机制尚未明确。有许多来自体内和体外动物研究的证据表明，合成的皮质类固醇，如地塞米松，抑制ACTH的合成或从脑垂体释放。在人类受试者中关于该主题的研究仍然很少（Fang，Tricon，Robertson and Meltzer 1981 ; Fehm，Voigt，库默，Lang and Pfeiffer 1979）。我们的研究是为了确定以常用剂量肌肉注射糖皮质激素的贮库形式对血浆皮质醇、ACTH和β-内啡肽（B-EP）水平的影响。我们检查了12名哮喘患者，男女都没有任何激素和代谢紊乱。将60 mg的丙酮化合物曲安奈德（Keneton 40®，E.R. Squibb & S.）被肌肉注射在即将注射凯奈替尼之前和注射凯奈替尼后第3、7、14、21和35天，始终在上午8：00至10：00之间采集血样。使用商业试剂盒（皮质醇和ACTH -阿默舍姆，B-EP -新英格兰Nuclear）对所有研究物质进行放射免疫测定。我们的发现（见图1）表明，一剂贮库形式的曲安西龙对ACTH血浆水平没有影响，并且与Clement-Jones，Lowry，Ress和Besser（1980）描述的结果不同，Clement-Jones，Lowry，Ress和Besser（1980）观察到7名正常受试者在给予2 mg地塞米松后血浆ACTH降低，
Although the inhibitory effect of exogenous glucocorticoids on the hypothalamus-pituitary-adrenal axis has been long known, the site and mechanism of this effect has not been definitely established. There are many evidences from in vivo and in vitro animal studies indicating that synthetic corticosteroids, such as dexamethasone, suppress ACTH synthesis or release from the pituitary gland. The studies on this topic in human subjects are still scant (Fang, Tricon, Robertson and Meltzer 1981 ; Fehm, Voigt, Kummer, Lang and Pfeiffer 1979). Our study was undertaken to determine the influence of the depot-form of glucocorticoid administered intramuscularly in a common ly used dose on plasma Cortisol, ACTH and beta-endorphin (B-EP) levels. We examined 12 asthmatic patients of both sexes without any hormonal and metabolic disorders. 60 mg of acetonide triamcinolone (Kenalog 40®, E.R. Squibb & S.) was injected i.m. The blood samples were collected immediately before and on the 3-rd, 7-th, 14-th, 21-st and 35-th day after Kenalog injection, always between 8.00 and 10.00 a.m. All the investigated substances were determined radioimmunologically using commercial kits (Cortisol and ACTH - Amersham, B-EP - New England Nuclear). Our findings (see Fig. 1) suggest that one dose of the depot-form of triamcinolone has not effect on ACTH plasma level and are different from the results described by Clement-Jones, Lowry, Ress and Besser (1980) who have observed a decrease of plasma ACTH after 2 mg dexamethasone given to 7 normal subjects at