Cross frequency coupling in next generation inhibitory neural mass models
Cross frequency coupling in next generation inhibitory neural mass models
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DOI：
10.1063/1.5125216
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发表时间：
2020-05-01
期刊：
影响因子：
2.9
通讯作者：
Angulo-Garcia, David
中科院分区：
文献类型：
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作者：
Ceni, Andrea;Olmi, Simona;Angulo-Garcia, David
神经节律之间的耦合是大脑认知过程基础上最重要的机制之一。在这项研究中，我们考虑了一个神经质量模型，该模型是从具有指数突触的抑制性尖峰网络的微观动力学中严格获得的，能够自主生成集体振荡（CO）。这些振荡通过超临界 Hopf 分岔出现，其频率由突触时间尺度、突触耦合和神经群的兴奋性控制。此外，我们表明，具有不同突触时间尺度的主从配置中的两个抑制群体可以表现出各种集体动态机制：朝向稳定焦点的阻尼振荡、周期性和准周期性振荡以及混沌。最后，当双向耦合时，两个抑制群体可以表现出不同类型的θ-γ交叉频率耦合（CFC）：相位-相位和相位-幅度CFC。 θ 和 γ CO 之间的耦合在存在外部 θ 强迫的情况下会增强，这让人想起通过光遗传学驱动在海马和皮层回路中诱导的调制类型。
Coupling among neural rhythms is one of the most important mechanisms at the basis of cognitive processes in the brain. In this study, we consider a neural mass model, rigorously obtained from the microscopic dynamics of an inhibitory spiking network with exponential synapses, able to autonomously generate collective oscillations (COs). These oscillations emerge via a super-critical Hopf bifurcation, and their frequencies are controlled by the synaptic time scale, the synaptic coupling, and the excitability of the neural population. Furthermore, we show that two inhibitory populations in a master-slave configuration with different synaptic time scales can display various collective dynamical regimes: damped oscillations toward a stable focus, periodic and quasi-periodic oscillations, and chaos. Finally, when bidirectionally coupled, the two inhibitory populations can exhibit different types oftheta-gamma cross-frequency couplings (CFCs): phase-phase and phase-amplitude CFC. The coupling betweentheta andgamma COs is enhanced in the presence of an externaltheta forcing, reminiscent of the type of modulation induced in hippocampal and cortex circuits via optogenetic drive.