An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl-Mediated in situ Activation of ,-Unsaturated Carboxylic Acids
An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl-Mediated in situ Activation of ,-Unsaturated Carboxylic Acids
复制标题
通过 NHC/LiCl 介导的 ,-不饱和羧酸原位活化对二氢吡喃酮进行对映选择性组装
DOI：
10.1002/asia.201501353
复制
发表时间：
2016-03-04
影响因子：
4.1
通讯作者：
Yao, Changsheng
中科院分区：
文献类型：
--
作者：
Que, Yonglei;Lu, Yinan;Yao, Changsheng
通过原位活化策略实现了N-杂环卡宾（NHC）/LiCl介导的，-不饱和羧酸和1，3-二羰基化合物的直接合成.该方案的主要优点包括原料的易得性和高稳定性、良好的产率和优异的对映选择性。
A straightforward N-heterocyclic carbene (NHC)/LiCl-mediated synthesis of dihydropyranones from ,-unsaturated carboxylic acids and 1,3-dicarbonyl compounds was realized through the in situ activation strategy. The key advantages of this protocol include ready availability and high stability of starting materials, good yields, and excellent enantioselectivity.