The Acceptability and Potential Utility of Cognitive Training to Improve Working Memory in Persons Living With HIV: A Preliminary Randomized Trial.
The Acceptability and Potential Utility of Cognitive Training to Improve Working Memory in Persons Living With HIV: A Preliminary Randomized Trial.
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DOI：
10.1016/j.jana.2017.03.007
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Meade CS
中科院分区：
文献类型：
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作者：
Towe SL;Patel P;Meade CS
影响日常功能的艾滋病毒相关神经认知障碍在有效的抗逆转录病毒治疗时代仍然存在。认知训练是一种前景看好的低成本干预措施，已被证明可以改善一些临床人群的神经认知功能。我们测试了计算机化认知训练的可行性、可接受性和初步效果，以改善艾滋病毒感染者(PLWH)和工作记忆受损患者的工作记忆。在这项随机临床试验中，我们将21名成人PLWH分配到实验性认知训练干预或注意力匹配的对照训练干预中。参与者在10周内完成了12次培训，并在基线和培训后进行了评估。会议出席率很高，参与者对该计划给予了积极的评价。试验组的参与者表现出随着时间的推移工作记忆功能有所改善，而控制组的参与者则没有变化。我们的结果表明，认知训练可能是一种有前途的干预工作记忆损害的PLWH，应该进一步评估。
HIV-associated neurocognitive impairments that impact daily function persist in the era of effective antiretroviral therapy. Cognitive training, a promising low-cost intervention, has been shown to improve neurocognitive functioning in some clinical populations. We tested the feasibility, acceptability, and preliminary effects of computerized cognitive training to improve working memory in persons living with HIV infection (PLWH) and working memory impairment. In this randomized clinical trial, we assigned 21 adult PLWH to either an experimental cognitive training intervention or an attention-matched control training intervention. Participants completed 12 training sessions across 10 weeks with assessments at baseline and post-training. Session attendance was excellent and participants rated the program positively. Participants in the experimental arm demonstrated improved working memory function over time; participants in the control arm showed no change. Our results suggest that cognitive training may be a promising intervention for working memory impairment in PLWH and should be evaluated further.