Prevalence of HCV infection in nongastric marginal zone B-cell lymphoma of MALT
Prevalence of HCV infection in nongastric marginal zone B-cell lymphoma of MALT
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DOI：
10.1093/annonc/mdl388
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发表时间：
2007-02-01
影响因子：
50.5
通讯作者：
Lazzarino, M.
中科院分区：
文献类型：
--
作者：
Arcaini, L.;Burcheri, S.;Lazzarino, M.
背景：丙型肝炎病毒（HCV）感染常与B细胞非霍奇金淋巴瘤相关。我们调查了非胃粘膜相关淋巴组织（MALT）边缘区淋巴瘤中HCV感染的患病率，以确定病毒感染与表现特征、治疗和结局之间的关系。我们回顾性研究了172例组织学诊断为MALT边缘区B细胞淋巴瘤（胃除外）的患者，并进行了HCV血清学检查，结果：60例（35%）患者有HCV感染。大多数HCV阳性患者（97%）表现为单个MALT器官受累。HCV阳性患者表现出更常见的皮肤（35%），唾液腺（25%）和眼眶（15%）的参与。大多数IV期HCV阳性患者（71%）有单个MALT部位伴骨髓受累。HCV阳性患者（93%）和HCV阴性患者（87%）的总体缓解率相似。总生存期（OS）和无事件生存期（EFS）没有根据HCV感染的差异。在多变量分析中，先进的疾病（阶段III-IV）与较差的OS（P = 0.0001），无论HCV serotstatus.Conclusions：这项研究表明，非胃边缘区淋巴瘤的特点是HCV感染的高患病率。累及单个MALT部位的患者HCV患病率最高。HCV阳性非胃MALT淋巴瘤表现出与HCV阴性患者相似的无痛病程，似乎是利用抗病毒治疗抗淋巴瘤活性的理想靶点。
Background: Hepatitis C virus (HCV) infection is frequently associated with B-cell non-Hodgkin's lymphomas. We investigated the prevalence of HCV infection in nongastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) in order to define the relationship between the viral infection and the presenting features, treatment, and outcome.Methods: We retrospectively studied 172 patients with a histological diagnosis of marginal zone B-cell lymphoma of MALT, except for stomach, and with available HCV serology, among a series of 208 patients.Results: HCV infection was documented in 60 patients (35%). Most HCV-positive patients (97%) showed a single MALT organ involvement. HCV-positive patients showed a more frequent involvement of skin (35%), salivary glands (25%), and orbit (15%). The majority of stage IV HCV-positive patients (71%) had a single MALT site with bone marrow involvement. The overall response rate was similar in HCV-positive (93%) and HCV-negative patients (87%). Overall survival (OS) and event-free survival (EFS) did not differ according to HCV infection. In multivariate analysis, advanced disease (stage III-IV) was associated with a poorer OS (P = 0.0001), irrespective of HCV serostatus.Conclusions: This study shows that nongastric marginal zone lymphomas are characterized by a high prevalence of HCV infection. Patients with involvement of a single MALT site have the highest prevalence of HCV. HCV-positive nongastric lymphomas of MALT show an indolent course similar to HCV-negative patients and seem an ideal target for exploiting the antilymphoma activity of antiviral treatments.