A MUTATION OF THE CIRCADIAN SYSTEM IN GOLDEN-HAMSTERS
A MUTATION OF THE CIRCADIAN SYSTEM IN GOLDEN-HAMSTERS
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DOI：
10.1126/science.3413487
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发表时间：
1988-09-02
期刊：
影响因子：
56.9
通讯作者：
MENAKER, M
中科院分区：
文献类型：
--
作者：
RALPH, MR;MENAKER, M
已经发现一种突变，可以显著缩短金黄仓鼠的昼夜运动节律。这种突变的遗传模式表明，它发生在一个单一的常染色体基因座（tau）。野生型动物具有平均约24小时的自由运行周期的节律;突变的杂合子动物具有约22小时的周期，而纯合子动物具有接近20小时的周期的节律。携带突变等位基因的动物表现出异常夹带24小时光：暗周期或无法夹带。
A mutation has been found that dramatically shortens the period of the circadian locomotor rhythm of golden hamsters. The pattern of inheritance of this mutation suggests that it occurred at a single, autosomal locus (tau). Wild-type animals have rhythms with free-running periods averaging about 24 hours; animals heterozygous for the mutation have periods of about 22 hours, whereas homozygous animals have rhythms with periods close to 20 hours. Animals that carry the mutant alleles exhibited abnormal entrainment to 24-hour light:dark cycles or are unable to entrain.