Galacto-oligosaccharides Are Bifidogenic and Safe at Weaning: A Double-blind Randomized Multicenter Study
Galacto-oligosaccharides Are Bifidogenic and Safe at Weaning: A Double-blind Randomized Multicenter Study
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DOI：
10.1097/mpg.0b013e31817b6dd2
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Bertino, Enrico
中科院分区：
文献类型：
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作者：
Fanaro, Silvia;Marten, Berit;Bertino, Enrico
目的：本研究的主要目的是确定半乳低聚糖(GOS)在后续配方中的双歧化作用以及对其他肠道细菌的影响。参与者和方法：在一项多中心双盲研究中，159名健康婴儿在登记时(4-6个月)接受配方奶喂养，随机分为两组：试验性后续配方奶粉添加5g[L(GOS)(77例)]或标准后续配方奶粉(对照组，82例)。婴儿在登记时(研究第1天=SDL)、6周后(研究第2天=SD2)和另外12周后(研究第3天=SD3)进行评估。在每个研究日，收集新鲜的粪便样本进行细菌计数，并测量生长参数。结果：在SD2和SD3时，GOS组的双歧杆菌中位数(每克大便的菌落形成单位)高于对照组(SD2 GOS 9.2×10(9)vs对照组4.4×10(9)，P=0.012；SD3 GOS 7.2×10(9)vs对照组2.4×10(9)，P=0.027)。在所有研究日，两组之间的其他细菌没有显示出任何显著差异。GOS能产生更柔软的大便，但对大便频率没有影响。SD2时两组尿渗透压(mOsm/L)相近。结论：在后续配方奶粉中添加果寡糖(5g/L)对婴儿断奶时补充期间的双歧杆菌菌群和大便稠度有积极的影响。没有记录到局部或全身副作用。JPGN 48：82-88,2009。
Objectives: The primary objective of this study was to determine the bifidogenic effect of galacto-oligosaccharides (GOS) in a follow-on formula and the effects on other intestinal bacteria. Secondary objectives were the effects on stool characteristics, growth, and general well-being.Participants and Methods: In a multicenter, double-blind study, 159 healthy infants, formula-fed at enrollment (at 4-6 months), were randomized to an experimental follow-on formula supplemented with 5 g[L (GOS) (77 infants), or to a standard follow-on formula (control, 82 infants). Infants were evaluated at enrollment (study day 1=sdl), after 6 weeks (study day 2 = sd2), and after an additional 12 weeks (study day 3 = sd3). At each study day, a fresh stool sample for the bacterial counts was collected, and the growth parameters were measured. At sd2, urinary specimens were collected for the evaluation of urinary osmolarity.Results: At sd2 and sd3, the GOS group had a higher median number (colony-forming units per gram of stool) of bifidobacteria than did the control group (sd2 GOS 9.2 x 10(9) vs control 4.4 x 10(9), P = 0.0 12); (sd3 GOS 7.2 x 10(9) vs control 2.4 x 10(9), P = 0.027). Other bacteria did not show any significant differences between the 2 groups at all study days. The GOS produced softer stools but had no effect on stool frequency. The urinary osmolarity (mOsm/L) at sd2 was comparable in both groups. Supplementation had no influence on the incidence of gastrointestinal side effects or on the growth of the infants.Conclusions: These data indicate that the addition of GOS (5 g/L) to a follow-on formula positively influences the bifidobacteria flora and the stool consistency in infants during the supplementation period at weaning. No local or systemic side effects were recorded. JPGN 48:82-88, 2009.