Dyslexia Diagnostics by 3-D Shape Analysis of the Corpus Callosum
Dyslexia Diagnostics by 3-D Shape Analysis of the Corpus Callosum
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DOI：
10.1109/titb.2012.2187302
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发表时间：
2012-07-01
影响因子：
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通讯作者：
El-Baz, Ayman
中科院分区：
文献类型：
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作者：
Elnakib, Ahmed;Casanova, Manuel F.;El-Baz, Ayman
阅读障碍严重损害学习能力；因此，需要改进的诊断方法。神经病理学研究揭示了阅读障碍大脑中胼胝体（CC）的异常解剖结构。我们提出了一种对大脑 3D 磁共振图像 (MRI) 进行定量分析的新方法，确保更准确地量化诵读困难受试者和对照受试者的 CC 之间的解剖差异。所提出的方法包括三个主要处理步骤：1）使用学习的 CC 形状和视觉外观从给定的 3-DMRI 中分割 CC； 2）提取CC的中心线； 3) CC 表面的柱面映射以进行比较分析。对 3D 模拟体模的验证证明了所提出的方法能够准确检测两个 3D 表面之间的形状变化。实验结果显示，14 名正常人和 16 名阅读困难受试者在所有四个解剖部分（即压部、讲台、膝部和 CC 体部）之间存在显着差异（95% 置信水平）。此外，基于中心线长度和 CC 厚度的初步分类结果表明，所提出的形状分析是对当前诊断阅读障碍技术的有希望的补充。
Dyslexia severely impairs learning abilities; therefore, improved diagnostic methods are needed. Neuropathological studies have revealed an abnormal anatomy of the corpus callosum (CC) in dyslexic brains. We propose a new approach for the quantitative analysis of 3-D magnetic resonance images (MRI) of the brain that ensures a more accurate quantification of anatomical differences between the CC of dyslexic and control subjects. The proposed approach consists of three main processing steps: 1) segmenting the CC from a given 3-DMRI using the learned CC shape and visual appearance; 2) extracting the centerline of the CC; and 3) cylindrical mapping of the CC surface for its comparative analysis. Validation on 3-D simulated phantoms demonstrates the ability of the proposed approach to accurately detect the shape variability between two 3-D surfaces. Experimental results revealed significant differences (at the 95% confidence level) between 14 normal and 16 dyslexic subjects in all four anatomical divisions, i.e., splenium, rostrum, genu, and body of their CCs. Moreover, the initial classification results based on the centerline length and CC thickness suggest that the proposed shape analysis is a promising supplement to the current techniques for diagnosing dyslexia.