Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats
Influence of psychogenic and neurogenic stressors on neuroendocrine and central monoamine activity in fast and slow kindling rats
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DOI：
10.1016/s0006-8993(99)01771-0
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发表时间：
1999-09-04
期刊：
影响因子：
2.9
通讯作者：
Anisman, H
中科院分区：
文献类型：
--
作者：
McIntyre, DC;Kent, P;Anisman, H
中枢神经化学和神经内分泌影响的心因性（雪貂暴露）和神经源性（约束）的压力进行了评估，在大鼠中，已被选择性繁殖的杏仁核兴奋性的差异表现为快速或缓慢杏仁核点燃癫痫。虽然这些大鼠的情绪不同，但它们的行为方式取决于它们所暴露的压力源的性质。在束缚期间，慢老鼠大多不动，而快老鼠持续挣扎。相比之下，快速大鼠对雪貂的反应更不灵活。然而，更情绪化的慢大鼠表现出更大的皮质酮反应的雪貂，而可比的皮质酮反应线之间是明显的约束。尽管两种应激源都影响了通常与应激源相关的脑区域（例如，蓝斑、下丘脑室旁核、杏仁核、前额叶皮质），杏仁核内侧核和基底外侧核的胺变化明显，但中央核的胺变化不明显。此外，更大的NE变化是明显的内侧杏仁核的左半球。同样，DA的变化也更大，在左内侧杏仁核的压力。尽管行为风格非常不同，然而，这两条线往往表现出类似的胺变化，以应对这两种压力。(C)1999年由Elsevier Science B.V.出版，版权所有。
The central neurochemical and neuroendocrine effects of a psychogenic (ferret exposure) and a neurogenic (restraint) stressor were assessed in rats that had been selectively bred for differences in amygdala excitability manifested by either Fast or Slow amygdala kindling epileptogenesis. While these rat lines differ in their emotionality, their behavioral styles were dependent on the nature of the stressor to which they were exposed. During restraint, the Slow rats were mostly immobile, while Fast rats persistently struggled. In contrast, Fast rats were more immobile in response to the ferret. Yet, the more emotional Slow rats exhibited a greater corticosterone response to the ferret, while comparable corticosterone responses between lines were evident following restraint. Although both stressors influenced norepinephrine (NE), dopamine (DA) and/or serotonin (5-HT) activity in brain regions typically associated with stressors (e.g., locus coeruleus, paraventricular nucleus of the hypothalamus, nucleus accumbens, prefrontal cortex), considerable amine alterations were evident in the medial and basolateral amygdala nuclei, but not in the central nucleus. Moreover, greater NE changes were apparent in the medial amygdala of the left hemisphere. Similarly, DA alterations also were greater in the left medial amygdala in response to stressors. Despite very different behavioral styles, however, the two lines often exhibited similar amine alterations in response to both stressors. (C) 1999 Published by Elsevier Science B.V. All rights reserved.