Dopamine metabolites and catalepsy after lithium and haloperidol.
Dopamine metabolites and catalepsy after lithium and haloperidol.
复制标题
锂和氟哌啶醇后的多巴胺代谢和僵直症。
DOI：
10.1016/0014-2999(82)90378-8
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发表时间：
1982
影响因子：
5
通讯作者：
Rozitis,A
中科院分区：
文献类型：
--
作者：
BowersJr,MB;Rozitis,A
鼠粮中给药锂使大鼠尾状核内多巴胺代谢物（DOPAC和HVA）少量增加，但皮质内未增加，并增强氟哌啶醇给药后2天内这两个区域内多巴胺代谢物的增加。给予氟哌啶醇10天，锂减弱尾状核对DA代谢物增加的耐受性。当与氟哌啶醇联合用药22天时，锂阻止了对每日单独服用氟哌啶醇所产生的嗜睡的耐受性。锂可以增加和延长局部DA代谢物的增加，延长慢性氟哌啶醇引起的麻痹持续时间。
Lithium administered in chow produced a small increase in DA metabolites (DOPAC and HVA) in rat caudate but not cortex and augmented the increase in DA metabolites in both regions produced by haloperidol administration for 2 days. Given for 10 days with haloperidol, lithium attenuated the tolerance to an increase in DA metabolites in caudate. When administered with haloperidol for 22 days, lithium prevented the tolerance to catalepsy produced by daily administration of haloperidol alone. Lithium can augment and prolong the increase in regional DA metabolites and extend the duration of catalepsy produced by chronic haloperidol.