Anti-inflammatory modalities: Their current use in pediatric cardiac surgery in the United Kingdom and Ireland
Anti-inflammatory modalities: Their current use in pediatric cardiac surgery in the United Kingdom and Ireland
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DOI：
10.1097/pcc.0b013e3181a3105d
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发表时间：
2009-05-01
影响因子：
4.1
通讯作者：
Macrae, Duncan
中科院分区：
文献类型：
--
作者：
Allen, Meredith;Sundararajan, Santosh;Macrae, Duncan
目的：确定抗炎治疗在英国和爱尔兰接受心脏手术的婴儿和儿童中的使用情况。设计：问卷调查。受试者：英国和爱尔兰进行小儿心脏手术的所有中心。结果。所有中心都使用至少一种抗炎治疗，46%的中心使用一种以上。改良超滤（80%）和类固醇（80%）都被广泛用作抗炎策略。在使用类固醇的中心中，类固醇的剂量、制备和给药时间。高度可变。肝素结合电路和抑肽酶很少被用作抗炎technology.Conclusion：虽然抗炎干预措施被认为有助于改善心肺转流术后患者的预后，这项调查表明，在实践中仍然存在广泛的变化。我们认为，这反映了缺乏支持临床获益的良好证据，而不是反映了不良的临床实践。（Pediatr Crit Care Med 2009; 10：341-345）
Objective: To determine the use of anti-inflammatory therapies in infants and children undergoing cardiac surgery in the United Kingdom and Ireland.Design: Questionnaire survey.Subjects: All centers that undertake pediatric cardiac surgery in the United Kingdom and Ireland.Results. All centers use at least one anti-inflammatory therapy, with 46% of centers using more than one. Both modified ultrafiltration (80%) and steroids (80%) are widely used as anti-inflammatory strategies. Among centers that use steroids, dose, preparation, and timing of steroid administered was. highly variable. Heparin-bonded circuits and aprotinin are infrequently used as anti-inflammatory techniques.Conclusion: Although anti-inflammatory interventions are believed to contribute to improved patient outcome following cardiopulmonary bypass, this survey has shown that there are still widespread variations in practice. Rather than reflecting poor clinical practice, we believe this reflects a lack of good evidence supporting clinical benefit. (Pediatr Crit Care Med 2009; 10: 341-345)