A nanofluidic railroad switch for DNA
A nanofluidic railroad switch for DNA
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DOI：
10.1021/nl061137b
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发表时间：
2006-09-13
期刊：
影响因子：
10.8
通讯作者：
Sturm, James C.
中科院分区：
文献类型：
--
作者：
Riehn, Robert;Austin, Robert H.;Sturm, James C.
我们提出了一种在熔融二氧化硅中由二维、不对称的交叉纳米通道晶格组成的超材料，其通道直径从80 nm到140 nm。当DNA被引入时，它被拉伸和线性化。我们发现，通道尺寸的不对称性导致了DNA取向的优先方向和DC电泳法下的优先运输方向。有趣的是，通过施加交流电压，优选的取向和传输轴可以切换90。我们用聚电解质的能量图景来解释这一结果，该图景由熵和介电作用组成，其强度和符号可以通过改变交流电场强度来调节。
We present a metamaterial consisting of a two-dimensional, asymmetric lattice of crossed nanochannels in fused silica, with channel diameters of 80 nm to 140 nm. When DNA is introduced, it is stretched and linearized. We show that the asymmetry in channel dimensions gives rise to a preferred direction for DNA orientation and a preferred direction for transport under dc electrophoresis. Interestingly, the preferred axis of orientation and transport can be switched by 90 through application of an ac voltage. We explain the results in terms of an energy landscape for polyelectrolytes that consists of entropic and dielectrophoretic contributions and whose strength and sign can be tuned by changing the ac field strength.