Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women.
Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women.
复制标题
雌性小鼠的突变频率和女性辐射遗传危害的估计。
DOI：
10.1073/pnas.74.8.3523
复制
发表时间：
1977
影响因子：
11.1
通讯作者：
W. Russell
中科院分区：
文献类型：
--
作者：
W. Russell
在辐射遗传危害中最重要的雌性生殖细胞阶段是未成熟的、滞留的卵母细胞。在小鼠中，这一阶段对辐射诱导突变的敏感性几乎为零或为零。然而，将这些小鼠研究结果应用于女性受到质疑，理由是小鼠的卵母细胞对辐射杀伤高度敏感，而人类细胞则不然；而且，小鼠体内成熟的和正在成熟的卵母细胞对杀伤有抵抗力，对突变诱导很敏感。目前的结果对这个问题有双重影响。首先，对卵母细胞阶段对杀伤和突变诱导的敏感性进行更详细的分析表明，两者之间没有一致的相关性，无论是负相关性还是正相关性。这表明小鼠未成熟卵母细胞对细胞杀伤的敏感性可能不足以阻止其用于预测人类未成熟卵母细胞的突变反应。其次，如果做出更谨慎的假设，即人类捕获的卵母细胞可能与小鼠中最敏感的卵母细胞阶段（即成熟卵母细胞和成熟卵母细胞）一样具有突变敏感性，那么目前关于这些阶段持续时间的数据可以比迄今为止对这些阶段对慢性辐射的突变反应进行更准确的估计。
The female germ cell stage of primary importance in radiation genetic hazards is the immature, arrested oocyte. In the mouse, this stage has a near zero or zero sensitivity to mutation induction by radiation. However, the application of these mouse results to women has been questioned on the ground that the mouse arrested oocytes are highly sensitive to killing by radiation, while the human cells are not; and, furthermore, that the mature and maturing oocytes in the mouse, which are resistant to killing, are sensitive to mutation induction. The present results have a 2-fold bearing on this problem. First, a more detailed analysis of oocyte-stage sensitivity to killing and mutation induction shows that there is no consistent correlation, either negative or positive, between the two. This indicates that the sensitivity to cell killing of the mouse immature oocyte may not be sufficient reason to prevent its use in predicting the mutational response of the human immature oocyte. Second, if the much more cautious assumption is made that the human arrested oocyte might be as mutationally sensitive as the most sensitive of all oocyte stages in the mouse, namely the maturing and mature ones, then the present data on the duration of these stages permit more accurate estimates than were heretofore possible on the mutational response of these stages to chronic irradiation.