Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis.
Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis.
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APEX1 Asp148Glu 多态性与前列腺癌（尤其是亚洲人）之间的关联：一项新的循证分析
DOI：
10.18632/oncotarget.9693
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发表时间：
2016-08-09
期刊：
影响因子：
--
通讯作者：
Mo Z
中科院分区：
文献类型：
--
作者：
Chen Y;Li J;Mo Z
背景前列腺癌（Pca）是一种严重的疾病，其发病率和死亡率相当高. Asp 148 Glu多态性作为一个致病因素已被确定在脱嘌呤/脱嘧啶核酸内切酶（APEX 1）基因。然而，亚洲人之间的关联被认为是有争议的。方法从PubMed、Embase、HuGENet和中国知网（CNKI）数据库中获取相关证据。在分析中，使用了四种模型。基于Gleason评分、前列腺特异性抗原表达和临床状态，评估APEX 1多态性与Pca侵袭性之间的关联。结果7篇文献纳入分析。阳性结果不仅在汇总分析中发现，而且在混合血统和亚洲血统的患者中也发现。然而，在考虑Hardy-Weinberg平衡（HWE）后，我们观察到在共显性模型下，亚裔受试者的Pca风险仅增加1.557倍（GG vs. TT：OR=1.557，95%CI=1.069-2.268）。此外，我们也没有发现APEX 1 Asp 148 Glu多态性与侵袭性Pca风险之间的任何关系。结论APEX 1 Asp 148 Glu多态性可能是Pca发病的重要因素，而不是Pca的侵袭性。
Background Prostate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial. Methods Evidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated. Results Seven articles were included in the analysis. Positive results were not only discovered in the pooled analysis, but also among patients of mixed descentand Asian descent. However, after considering the Hardy-Weinberg equilibrium (HWE), we observed only a 1.557-fold increase in Pca risk for subjects of Asian descent(GG vs. TT: OR=1.557, 95%CI=1.069-2.268) under the co-dominant model. Additionally, we did not also find any relationship between the APEX1 Asp148Glu polymorphism and invasive Pca risk. Conclusion On the basis of the function of the APEX1 Asp148Glu polymorphism, recent studies, and our results, we suggest that the APEX1 Asp148Glu polymorphism might be important in stimulating the development of Pca rather than its invasiveness in various populations, especially for Asians.