Maternal protein malnutrition during gestation alone and its effects on plasma insulin levels of the pregnant pig, its fetuses and the developing offspring.
Maternal protein malnutrition during gestation alone and its effects on plasma insulin levels of the pregnant pig, its fetuses and the developing offspring.
复制标题
妊娠期间母体蛋白质营养不良及其对怀孕猪、胎儿和发育中后代血浆胰岛素水平的影响。
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
R. Barnes
中科院分区：
文献类型：
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作者：
T. Atinmo;C. Baldijåo;W. Pond;R. Barnes
本文研究了限制蛋白质摄入对妊娠猪、胎儿和仔猪血浆胰岛素的影响。妊娠猪在整个妊娠期分别饲喂含18%、3%和0.5%蛋白质的日粮。在妊娠10、13和15周时，在母鼠放血后从子宫中取出胎仔。血浆样品用于通过放射免疫测定法测定胰岛素。在妊娠第15周，饲喂18%蛋白质的妊娠猪及其胎儿的血浆胰岛素水平显著高于其他两组。胎儿胰岛素水平与胎儿生长速度高度相关（r = 0.84）。来自另一组妊娠猪的两日龄pld猪在妊娠期间饲喂含18%、3%或0.5%蛋白质的饮食，与对照哺乳母鼠交叉培养，并在4周龄时断奶至标准饮食。定期采集血浆样品用于胰岛素测定。在妊娠期饲喂0.5%蛋白质的猪的后代在出生后的生活中始终低胰岛素水平，尽管断奶后的交叉寄养和标准喂养。似乎控制母体胰岛素分泌和胎盘转移的刺激之一是母体蛋白质摄入，而严重的母体蛋白质限制可能导致出生后后代胰岛素水平低。
The effects of restricting protein intake on plasma insulin were studied in pregnant pigs, fetuses and the developing offspring. Pregnant pigs were fed diets containing 18%, 3% or 0.5% protein throughout the gestation period. At 10, 13 and 15 weeks of gestation, fetuses were removed from the uterus after bleeding the dam. Plasma samples were used for insulin determination by a radioimmunoassay procedure. At week 15 of gestation, plasma insulin levels were significantly higher in pregnant pigs fed 18% protein and also in their fetuses than in the other two groups. There was a high correlation between fetal insulin level and fetal growth rate (r = 0.84). Two-day-pld pigs from another set of pregnant pigs fed the diet containing 18%, 3%, or 0.5% protein during gestation were cross-fostered to control nursing dams and weaned at 4 weeks of age to a standard diet. Plasma smaples obtained at regular intervals were used for insulin determination. Offspring of pigs fed 0.5% protein during gestation had consistently low insulin levels in postnatal life in spite of cross-fostering and standard feeding after weaning. It appears that one of the stimuli which control maternal insulin secretion and placenta transfer is the maternal protein intake while severe maternal protein restriction might contribute to the low levels of insulin in the progeny during postnatal life.