Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken
Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken
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DOI：
10.1016/j.intimp.2004.03.008
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发表时间：
2004-07-01
影响因子：
5.6
通讯作者：
Li, XG
中科院分区：
文献类型：
--
作者：
Kong, XF;Hu, YL;Li, XG
本试验旨在研究中草药成分对纽卡斯尔疫苗免疫雏鸡外周血淋巴细胞增殖和血清抗体效价的影响。选择9种CHMI进行实验。黄芪多糖（APS）、板蓝根多糖（IRPS）、淫羊藿黄酮（EF）、蜂胶黄酮（PF）、黄芪总苷（AS）和人参总苷（GS）均能促进淋巴细胞增殖和抗体滴度的升高，而淫羊藿多糖（EPS）主要是刺激细胞免疫反应。当归多糖（CAPS）和蜂胶多糖（PPS）的免疫促进作用较弱。APS、IRPS、PPS、PF促进淋巴细胞增殖作用高剂量组明显强于低剂量组，IRPS、PPS、EF、PF促进体液免疫作用高剂量组明显强于低剂量组。结果表明，这9种中药注射剂几乎都具有促进体液免疫和细胞免疫的作用，有望成为新型免疫增强剂的组分药物。(C)2004年由Elsevier B.V.出版
The purpose of these experiments is to study the effects of Chinese herbal medicinal ingredients (CHMIs) on peripheral lymphocyte proliferation and serum antibody titer in chicken vaccinated with Newcastle disease (ND) vaccine. Nine CHMIs were chosen for the experiments. Astragalus polysaccharide (APS), Isatis root polysaccharide (IRPS), Epimedium flavone (EF), Propolis flavone (PF), Astragalosides (AS) and Ginsenosides (GS) could promote lymphocyte proliferation and antibody titer, while Epimedium polysaccharide (EPS) mainly stimulated cellular immune responses. Chinese angelica polysaccharide (CAPS) and Propolis polysaccharide (PPS) exerted weaker effects on promoting immune responses. APS, IRPS, PPS and PF in promoting lymphocyte proliferation, and IRPS, PPS, EF and PF in promoting humoral immunity in higher dose were significantly stronger than in lower dose. Our results indicated that almost all of the nine CHMIs could promote both humoral and cellular immune responses and would be expected as the component drug of a new-type immunopotentiator. (C) 2004 Published by Elsevier B.V.