pH Clock-Operated Mechanized Nanoparticles
pH Clock-Operated Mechanized Nanoparticles
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DOI：
10.1021/ja9010157
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发表时间：
2009-09-16
影响因子：
15
通讯作者：
Zink, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Angelos, Sarah;Khashab, Niveen M.;Zink, Jeffrey I.
机械化纳米粒子（MNP）由连接到介孔二氧化硅纳米粒子表面的超分子机器组成，被设计成在pH活化下可控地释放封装的客体分子。分子机器由葫芦[6]脲（CB[6]）环组成，这些环环绕着拴系的三铵茎杆，并且可以通过茎杆的化学修饰来调节以在特定的pH条件下做出响应。发光光谱表明，MNP能够在中性pH水平下在纳米孔内包含客体分子，然后一旦pH降低或升高就释放它们。
Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.