Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release
Monoclonal antibody targeting chikungunya virus envelope 1 protein inhibits virus release
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DOI：
10.1016/j.virol.2014.05.038
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发表时间：
2014-09-01
期刊：
影响因子：
3.7
通讯作者：
Okabayashi, Tamaki
中科院分区：
文献类型：
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作者：
Masrinoul, Promsin;Puiprom, Orapim;Okabayashi, Tamaki
基孔肯雅病毒（CHIKV）引起一种急性临床疾病，其特征是突然高热、剧烈关节痛和皮疹。最近在非洲和亚洲暴发的基孔肯雅病是一个重大的公共卫生问题；然而，目前没有有效的许可疫苗或特定的治疗方法。本研究报道了一种小鼠单克隆抗体CK47的开发，该抗体识别病毒包膜1蛋白内的结构域III并抑制病毒释放过程，从而阻止子代病毒的产生。单抗对病毒进入和复制过程没有影响。因此，CK47可能是研究CHIKV释放机制的有用工具，并可能显示出作为治疗剂的潜力。(C) 2014爱思唯尔公司版权所有。
Chikungunya virus (CHIKV) causes an acute clinical illness characterized by sudden high fever, intense joint pain, and skin rash. Recent outbreaks of chikungunya disease in Africa and Asia are a major public health concern; however, there is currently no effective licensed vaccine or specific treatment. This study reported the development of a mouse monoclonal antibody (MAb), CK47, which recognizes domain III within the viral envelope 1 protein and inhibited the viral release process, thereby preventing the production of progeny virus. The MAb had no effect on virus entry and replication processes. Thus, CK47 may be a useful tool for studying the mechanisms underlying CHIKV release and may show potential as a therapeutic agent. (C) 2014 Elsevier Inc. All rights reserved.