CONTROL OF OXIDATIVE-METABOLISM AND OXYGEN DELIVERY IN HUMAN SKELETAL-MUSCLE - A STEADY-STATE ANALYSIS OF THE WORK ENERGY-COST TRANSFER-FUNCTION
CONTROL OF OXIDATIVE-METABOLISM AND OXYGEN DELIVERY IN HUMAN SKELETAL-MUSCLE - A STEADY-STATE ANALYSIS OF THE WORK ENERGY-COST TRANSFER-FUNCTION
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DOI：
10.1073/pnas.82.24.8384
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发表时间：
1985-12-01
影响因子：
11.1
通讯作者：
SMITH, D
中科院分区：
文献类型：
--
作者：
CHANCE, B;LEIGH, JS;SMITH, D
器官性能（功输出与生化输入）的传递函数的概念是在稳态运动条件下为骨骼肌和心肌开发的。对于ADP浓度的代谢控制，传递函数近似于Michaelis-Menten双曲线。变化的工作确定代谢工作点的传递函数对应的ADP浓度或无机磷酸盐磷酸肌酸的比例，可以确定由磷核磁共振。该操作点的特征在于在稳态下氧化代谢的最大活性的分数（V/Vmax）。这个数量似乎是有用的，在预测代谢稳态的程度是有效的;控制不良的代谢状态可以很容易地识别，并用于诊断和治疗代谢疾病的器官的新生儿和成人。
The concept of transfer function for organ performance (work output vs. biochemical input) is developed for skeletal and cardiac muscle under steady-state exercise conditions. For metabolic control by the ADP concentration, the transfer function approximates a Michaelis-Menten hyperbola. Variation of the work identifies metabolic operating points on the transfer function corresponding to ADP concentrations or to a ratio of inorganic phosphate to phosphocreatine that can be determined by phosphorus nuclear magnetic resonance. This operating point is characterized by the fraction (V/Vmax) of maximal activity of oxidative metabolism in the steady state. This quantity appears to be useful in predicting the degree to which metabolic homeostasis is effective; poorly controlled metabolic states can readily be identified and are used in the diagnosis and therapy of metabolic disease in the organs of neonates and adults.