Acute infantile gastroenteritis associated with human enteric viruses in Tunisia
Acute infantile gastroenteritis associated with human enteric viruses in Tunisia
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DOI：
10.1128/jcm.02438-07
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发表时间：
2008-04-01
影响因子：
9.4
通讯作者：
Pothier, Pierre
中科院分区：
文献类型：
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作者：
Sdiri-Loulizi, Khira;Gharbi-Khelifi, Hakima;Pothier, Pierre
这项前瞻性研究于2003年1月至2005年6月进行，调查了632名因急性腹泻在药房（380名儿童）或住院（252名儿童）的突尼斯儿童中引起婴儿胃肠炎的各种肠道病毒的发病率和临床作用。在276份样本中，每一份样本中至少发现一种肠道病毒（43.7%）。234份标本为单一病原体感染，42份标本为混合感染。在频率方面，轮状病毒和诺如病毒分别在22.5%和17.4%的样本中检出，其次是星状病毒（4.1%）、爱知病毒（3.5%）、腺病毒40型和41型（2.7%）以及沙波病毒（1.0%）。病毒性胃肠炎的季节分布呈现冬季高峰，但在5月至9月也有一个不寻常的高峰。评价住院婴儿腹泻的严重程度。在轮状病毒和诺如病毒感染的发病率和疾病的临床严重程度方面，特别是在脱水方面，没有观察到显著差异。
This prospective study, conducted from January 2003 to June 2005, investigated the incidence and the clinical role of various enteric viruses responsible for infantile gastroenteritis in 632 Tunisian children presenting in dispensaries (380 children) or hospitalized (252 children) for acute diarrhea. At least one enteric virus was found in each of 276 samples (43.7%). A single pathogen was observed in 234 samples, and mixed infections were found in 42 samples. In terms of frequency, rotavirus and norovirus were detected in 22.5 and 17.4% of the samples, respectively, followed by astrovirus (4.1%), Aichi virus (3.5%), adenovirus types 40 and 41 (2.7%), and sapovirus (1.0%). The seasonal distribution of viral gastroenteritis showed a winter peak but also an unusual peak from May to September. The severity of the diarrhea was evaluated for hospitalized infants. No significant differences were observed between rotavirus and norovirus infections with regard to the incidence and the clinical severity of the disease, especially in dehydration.