Contact pathway of coagulation and inflammation.
Contact pathway of coagulation and inflammation.
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DOI：
10.1186/s12959-015-0048-y
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发表时间：
2015
影响因子：
3.1
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Wu Y
接触系统又称血浆激肽释放酶-激肽系统，由凝血因子XII（FXII）、凝血因子XI（FXI）、血浆前激肽释放酶（PK）和非酶辅助因子高分子量激肽原（HK）组成。50多年来一直在积极研究这一制度。体外实验表明，该系统通过激活内源性通路而具有促血栓形成作用，通过产生生物活性肽缓激肽而具有促炎作用。尽管接触系统的激活与各种类型的人类疾病有关，但只有少数情况下其作用被明确定义。在过去的10年里，我们对接触系统的理解，特别是其生物学和（病理）生理学，通过使用基因修饰的动物模型的研究大大增加。在这篇综述中，我们将描述一个振兴的观点，接触系统作为一个关键的（病理）生理介质的凝血和炎症。
The contact system, also named as plasma kallikrein-kinin system, consists of three serine proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and the nonenzymatic cofactor high molecular weight kininogen (HK). This system has been investigated actively for more than 50 years. The components of this system and their interactions have been elucidated from in vitro experiments, which indicates that this system is prothrombotic by activating intrinsic pathway, and proinflammatory by producing bioactive peptide bradykinin. Although the activation of the contact system have been implicated in various types of human disease, in only a few instances is its role clearly defined. In the last 10 years, our understanding of the contact system, particularly its biology and (patho)physiology has greatly increased through investigations using gene-modified animal models. In this review we will describe a revitalized view of the contact system as a critical (patho)physiologic mediator of coagulation and inflammation.