Clinicopathological study of alcoholic fibrosis.
Clinicopathological study of alcoholic fibrosis.
复制标题
酒精性纤维化的临床病理学研究。
DOI：
--
复制
发表时间：
1982
影响因子：
9.8
通讯作者：
R. Kanayama
中科院分区：
文献类型：
--
作者：
A. Takada;J. Nei;Y. Matsuda;R. Kanayama
在112例酒精性肝损伤患者中，45例出现酒精性肝纤维化。酒精性肝纤维化的发生率为40.2%，在各种类型的酒精性肝损伤中最高（脂肪肝3.6%，酒精性肝炎2.7%，肝硬化31.3%）。酒精性肝纤维化的临床表现轻于肝硬化，重于脂肪肝。酒精性纤维化的平均实验室值与脂肪肝和肝硬化的平均实验室值有显著差异。实验室数据与细胞周围纤维化和终末肝小静脉增厚的存在有很好的相关性，但仅部分与肝细胞坏死相关，而与脂肪变性无关。两名酒精性纤维化患者在5年的随访中出现肝硬化，但没有任何肝炎的临床和组织学特征。这些结果表明，酒精性肝纤维化是日本最常见的酒精性肝损伤类型，是一个独立的临床病理实体不同于经典类型的酒精性肝损伤。细胞周纤维化和终末肝小静脉增厚是酒精性肝纤维化的主要组织学特征，可能在其向肝硬化的转化中起重要作用。
Among 112 patients with alcoholic liver injury, 45 had alcoholic fibrosis. The incidence of alcoholic fibrosis was 40.2% which was the highest among various types of alcoholic liver injury (fatty liver; 3.6%, alcoholic hepatitis; 2.7% and liver cirrhosis; 31.3%). Clinical features of alcoholic fibrosis were milder than those of liver cirrhosis and more severe than those of fatty liver. The mean laboratory values in alcoholic fibrosis were significantly different from those in fatty liver and liver cirrhosis. The laboratory data were well correlated with the presence of pericellular fibrosis and thickening of the terminal hepatic venule, but only partially with hepatic cell necrosis and not with fatty metamorphosis. Two patients with alcoholic fibrosis who developed cirrhosis without any clinical and histological features of hepatitis were observed during 5-yr follow-up. These results indicate that alcoholic fibrosis is the most common type of alcoholic liver injury in Japan and is an independent clinicopathological entity distinct from the classical types of alcoholic liver injury. Pericellular fibrosis and thickening of the terminal hepatic venule which are the main histological features of alcoholic fibrosis may play an important role in its transition to liver cirrhosis.