Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis.
Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis.
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DOI：
10.1016/j.jinf.2006.10.002
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发表时间：
2007-03-01
期刊：
影响因子：
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通讯作者：
Harrison, Thomas S
中科院分区：
文献类型：
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作者：
Brouwer, Annemarie E;Siddiqui, Asna A;Harrison, Thomas S
在明显免疫功能正常的个体中由加特隐球菌引起的脑膜炎的病理生理学仍不清楚。我们检测了一名HIV血清阴性、明显具有免疫活性的泰国C.在抗真菌治疗的前2周内发生了加特氏脑膜炎。促炎性IFN-γ、TNF-α和IL-6水平与HIV相关的新型隐球菌脑膜炎患者相比非常低，而IL-10水平非常高。C.格特脑膜炎可能是一个异质性的群体，这些数据表明，在这种情况下，对隐球菌暴露的不适应免疫反应已经允许发展为临床隐球菌疾病。
The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-gamma, TNF-alpha, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.