Co-transplantation of autologous OM-MSCs and OM-OECs: a novel approach for spinal cord injury
Co-transplantation of autologous OM-MSCs and OM-OECs: a novel approach for spinal cord injury
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自体 OM-MSC 和 OM-OEC 联合移植：治疗脊髓损伤的新方法
DOI：
10.1515/revneuro-2015-0030
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发表时间：
2016-04-01
影响因子：
4.1
通讯作者：
Lu, Ming
中科院分区：
文献类型：
--
作者：
Ge, Lite;Liu, Kai;Lu, Ming
摘要脊髓损伤（SCI）是一种严重的运动和感觉功能障碍性损伤。近年来，联合移植已成为SCI患者越来越多使用的治疗方法。骨髓间充质干细胞（MSCs）和嗅鞘细胞（OECs）已被用于改善SCI，并取得了良好的效果。骨髓间充质干细胞对脊髓损伤患者的康复有显著的效果。人嗅粘膜间充质干细胞具有增殖能力强、多向分化潜能大等特点，是临床上自体移植最理想的细胞来源之一。此外，从OM衍生的OECs已被用于改善SCI的功能恢复，并且多年来导致有希望的功能恢复。因此，已经采用与OM-OECs偶联的OM-MSCs共移植来改善SCI的恢复。在这里，我们回顾了已报道的OM-MSC和OM-OECs在SCI治疗中的应用，并提出使用自体OM-MSC和OM-OECs的新组合策略将实现SCI治疗的更好方法。
Abstract Spinal cord injury (SCI) is a disastrous injury that leads to motor and sensory dysfunctions in patients. In recent years, co-transplantation has become an increasingly used therapeutic treatment for patients with SCI. Both mesenchymal stem cells (MSCs) and olfactory-ensheathing cells (OECs) have been adopted to ameliorate SCI, with promising outcomes. Remarkable effects on the rehabilitation of patients with SCI have been achieved using MSCs. Olfactory mucosa (OM) MSCs from human OM are one of the most ideal cell resources for auto-transplantation in clinical application owing to their a high proliferation rate and multipotent capability. In addition, OECs derived from OM have been used to improve functional recovery of SCI and resulted in promising functional recovery in years. Accordingly, co-transplantation of OM-MSCs coupled with OM-OECs has been adopted to improve the recovery of SCI. Here we reviewed the reported applications of OM-MSCs and OM-OECs for SCI treatment and proposed that a novel combined strategy using both autologous OM-MSCs and OM-OECs would achieve a better approach for the treatment of SCI.