Central site of the hypertensive action of bradykinin.
Central site of the hypertensive action of bradykinin.
复制标题
缓激肽高血压作用的中心位点。
DOI：
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发表时间：
1975
影响因子：
3.5
通讯作者：
F. Graeff
中科院分区：
文献类型：
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作者：
F. Corrěa;F. Graeff
在用乌拉坦（1.5g/kg i. p.）麻醉的大鼠中，脑室注射1 μ g缓激肽（BK）。导致平均动脉血压升高，而脉压或心率变化很小或没有变化。在外侧隔区腹侧部局部给予0.5 μ g BK后，出现类似的高血压反应，而在已知参与心血管调节的其他皮质下区域局部应用BK则无影响。在外侧隔区腹侧部注射0.5或1 μ g合成P物质或1 μ g 9-去甲肾上腺素-缓激肽，血压没有变化。此外，双边电解病变放置在外侧隔区要么显着减少或完全阻断了升压反应，室内BK。这些结果表明，侧隔区腹侧部参与BK的升压作用在中枢神经系统。他们还表明，这个大脑区域相当具体地响应BK和局部血管的变化是不太可能参与调解的BK的中央行动。
The intraventricular injection of 1 mug of bradykinin (BK) in rats anesthetized with urethane (1.5 g/kg i.p.) caused an increase in mean arterial blood pressure with little or no change in pulse pressure or heart rate. A similar hypertensive response followed the local administration of 0.5 mug of BK at the pars ventralis of the lateral septal area, whereas local application at other subcortical regions, known to be involved in cardiovascular regulation, caused no effect. Injections of 0.5 or 1 mug of synthetic substance P or 1 mug of 9-desarginine-bradykinin at the pars ventralis of the lateral septal area caused no change in blood pressure. In addition, bilateral electrolytical lesions placed in the lateral septal area either markedly reduced or completely blocked the pressor response to intraventricular BK. These results suggest that the pars ventralis of the lateral septal area is involved in the pressor action of BK in the central nervous system. They also indicate that this brain region responds fairly specifically to BK and that local vascular changes are unlikely to be involved in the mediation of the central action of BK.